Sugi Predict

Sugi Predict / Compounds / SCHEMBL6447137

SCHEMBL6447137

SCHEMBL6447137

Nc1ccc(C(=O)c2ccccc2C(=O)O)cc1

nearest known ligand 0.73

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ AKR1C3 P42330 3/20 0.73
▸ CDC25B P30305 3/20 0.69
▸ ATM Q13315 1/20 0.69
▸ NR4A1 P22736 1/20 0.67
▸ CDC25A P30304 1/20 0.63
▸ HSD17B10 Q99714 1/20 0.63
▸ ALDH1A1 P00352 3/20 0.60
▸ POLB P06746 2/20 0.60
▸ CA1 P00915 1/20 0.58
▸ CA2 P00918 1/20 0.58
▸ CA9 Q16790 1/20 0.58
▸ GAA P10253 1/20 0.57
▸ MAPT P10636 1/20 0.57
▸ KDM4E B2RXH2 1/20 0.56
▸ ALOX15 P16050 1/20 0.56
▸ SRD5A2 P31213 1/20 0.48
▸ LMNA P02545 1/20 0.47
▸ CYP2C8 P10632 1/20 0.47
▸ CYP2C9 P11712 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28404270 0.92 MAPT (0.67) AKR1C3CDC25BATMNR4A1CDC25A
SCHEMBL10457007 0.92 GAA (0.59) AKR1C3CDC25BATMNR4A1CDC25A
SCHEMBL27524893 0.89 AKR1C3 (0.91) AKR1C3CDC25BATMNR4A1CDC25A
Phthalic Acid SCHEMBL9137413 0.87 ALDH1A1 (0.74) AKR1C3CDC25BATMCDC25AHSD17B10
SCHEMBL1614614 0.85 AKR1C3 (0.83) AKR1C3CDC25BATMNR4A1CDC25A
SCHEMBL30873149 0.85 AKR1C3 (0.83) AKR1C3CDC25BATMNR4A1CDC25A
2-Benzoylbenzoic Acid SCHEMBL30296847 0.85 AKR1C3 (1.00) AKR1C3CDC25BATMNR4A1CDC25A
2-Benzoylbenzoic Acid SCHEMBL76332 0.85 AKR1C3 (1.00) AKR1C3CDC25BATMNR4A1CDC25A
Water SCHEMBL30011179 0.83 AKR1C3 (0.79) AKR1C3CDC25BATMNR4A1CDC25A
2-Benzoylbenzoic Acid SCHEMBL9317427 0.83 AKR1C3 (0.95) AKR1C3CDC25BATMNR4A1CDC25A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110787663-B High permeability polymer composite membrane for gas separation and method of making the same 江西金海新能源科技有限公司 2020-11-06 — — CN claimed
CN-100387571-C Process for synthesizing 2-(4'-amino benzoyl) benzoic acid UNIV DONGHUA (CN) 2008-05-14 — — CN claimed
CN-1827587-A Process for synthesizing 2-(4'-amino benzoyl) benzoic acid UNIV DONGHUA (CN) 2006-09-06 — — CN claimed
CN-1775761-A 2, 4-di (4-aminophenyl)-2, 3-benzodiazine-1-one and its synthesizing method UNIV DONGHUA (CN) 2006-05-24 — — CN claimed
CN-110787663-B High permeability polymer composite membrane for gas separation and method of making the same 江西金海新能源科技有限公司 2020-11-06 — — CN disclosed
CN-105294622-B A kind of isoandrographolide class compound and preparation method and application 华南理工大学 2017-06-06 — — CN disclosed
CN-105294622-B A kind of isoandrographolide class compound and preparation method and application 华南理工大学 2017-06-06 — — CN disclosed
CN-100556933-C Contain 2, the PPTA and the manufacture method thereof of 4-two (4-aminophenyl)-2-1-ketone UNIV DONGHUA (CN) 2009-11-04 — — CN disclosed
CN-100387571-C Process for synthesizing 2-(4'-amino benzoyl) benzoic acid UNIV DONGHUA (CN) 2008-05-14 — — CN disclosed
CN-100387571-C Process for synthesizing 2-(4'-amino benzoyl) benzoic acid UNIV DONGHUA (CN) 2008-05-14 — — CN disclosed
CN-100387571-C Process for synthesizing 2-(4'-amino benzoyl) benzoic acid UNIV DONGHUA (CN) 2008-05-14 — — CN disclosed
CN-1827587-A Process for synthesizing 2-(4'-amino benzoyl) benzoic acid UNIV DONGHUA (CN) 2006-09-06 — — CN disclosed
CN-1827587-A Process for synthesizing 2-(4'-amino benzoyl) benzoic acid UNIV DONGHUA (CN) 2006-09-06 — — CN disclosed
CN-1827587-A Process for synthesizing 2-(4'-amino benzoyl) benzoic acid UNIV DONGHUA (CN) 2006-09-06 — — CN disclosed
CN-1793199-A PPTA containing 2,4 di (4-amino phenyl)-2,3-diaza naphthalene-1-one and preparation process thereof UNIV DONGHUA (CN) 2006-06-28 — — CN disclosed
CN-1775761-A 2, 4-di (4-aminophenyl)-2, 3-benzodiazine-1-one and its synthesizing method UNIV DONGHUA (CN) 2006-05-24 — — CN disclosed
US-20050143384-A1 Amide thiadiazole inhibitors of plasminogen activator inhibitor-1 BRISTOL-MYERS SQUIBB COMPANY 2005-06-30 — — US disclosed
EP-0569457-B1 USE OF THIAZOLO-[2,3-A]ISOINDOLE DERIVATIVES AS ANTIVIRAL MEDICAMENTS AND NOVEL THIAZOLO- [2,3-A]ISOINDOLE DERIVATIVES BOEHRINGER MANNHEIM GMBH (DE) 1995-06-14 — — EP disclosed
EP-0569457-A1 USE OF THIAZOLO- 2,3-A]ISOINDOLE DERIVATIVES AS ANTIVIRAL MEDICAMENTS AND NOVEL THIAZOLO- 2,3-A]ISOINDOLE DERIVATIVES. BOEHRINGER MANNHEIM GMBH (DE) 1993-11-18 — — EP disclosed
WO-1992013863-A1 USE OF THIAZOLO-[2,3-A]ISOINDOLE DERIVATIVES AS ANTIVIRAL MEDICAMENTS AND NOVEL THIAZOLO-[2,3-A]ISOINDOLE DERIVATIVES BOEHRINGER MANNHEIM GMBH (DE) 1992-08-20 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050143384-A1 Amide thiadiazole inhibitors of plasminogen activator inhibitor-1 SERPINE1, SERPINC1, SERPINB1 AKR1C3 302/4885CDC25B 3066/4885ATM 1322/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.