SCHEMBL6447374

SCHEMBL6447374

Nc1ccc(Oc2ccc(C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)cc2)c(N)c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 3/20 0.50
RAB9A P51151 3/20 0.50
MAPT P10636 10/20 0.47
LMNA P02545 2/20 0.47
ATM Q13315 2/20 0.47
NPSR1 Q6W5P4 1/20 0.41
ALDH1A1 P00352 6/20 0.40
MEN1 O00255 4/20 0.40
KMT2A Q03164 4/20 0.40
HPGD P15428 2/20 0.40
CYP1A2 P05177 2/20 0.40
CYP2C9 P11712 2/20 0.40
CYP2C19 P33261 2/20 0.40
KDM4E B2RXH2 2/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
CYP2D6 P10635 1/20 0.40
NPC1 O15118 2/20 0.36
MAPK1 P28482 1/20 0.36
CYP3A4 P08684 2/20 0.36
HTT P42858 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28271428 0.85 L3MBTL1 (0.52) L3MBTL1RAB9AMAPTLMNAATM
SCHEMBL28271430 0.84 L3MBTL1 (0.51) L3MBTL1RAB9AMAPTLMNAATM
SCHEMBL27739374 0.82 L3MBTL1 (0.55) L3MBTL1RAB9AMAPTLMNAATM
SCHEMBL29866140 0.82 L3MBTL1 (0.67) L3MBTL1RAB9AMAPTLMNAATM
SCHEMBL7023088 0.82 L3MBTL1 (0.67) L3MBTL1RAB9AMAPTLMNAATM
SCHEMBL9737743 0.80 L3MBTL1 (0.38) L3MBTL1RAB9AMAPTLMNAATM
SCHEMBL9737599 0.80 L3MBTL1 (0.38) L3MBTL1RAB9AMAPTLMNAATM
SCHEMBL9736024 0.78 L3MBTL1 (0.39) L3MBTL1RAB9AMAPTLMNAATM
SCHEMBL9578121 0.78 ALDH1A1 (0.57) RAB9AMAPTALDH1A1MEN1KMT2A
SCHEMBL10054741 0.78 L3MBTL1 (0.61) L3MBTL1RAB9AMAPTLMNAATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6927012-B2 Polyamic acid resin composition NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2005-08-09 US claimed
EP-1411088-B1 POLYAMIC ACID RESIN COMPOSITION NISSAN CHEMICAL IND LTD (JP) 2013-08-21 EP disclosed
US-6927012-B2 Polyamic acid resin composition NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2005-08-09 US disclosed
US-20040175646-A1 Polyamic acid resin composition NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2004-09-09 US disclosed
EP-1411088-A1 POLYAMIC ACID RESIN COMPOSITION Nissan Chemical Industries, Ltd. (JP) 2004-04-21 EP disclosed