Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.36 |
| ▸ | PLK1 | P53350 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PLD2 | O14939 | 1/20 | 0.33 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5991907 | 0.93 | EPHX2 (0.37) | KMT2ALMNASLC6A9PLK1MEN1 | |
| SCHEMBL4558520 | 0.92 | PDPK1 (0.39) | KMT2ALMNASLC6A9PLK1MEN1 | |
| SCHEMBL5990532 | 0.90 | NPC1 (0.36) | KMT2ALMNASLC6A9PLK1MEN1 | |
| SCHEMBL5983301 | 0.90 | SLC6A9 (0.33) | KMT2ASLC6A9MEN1RXFP1PLD2 | |
| SCHEMBL4330586 | 0.82 | SLC6A9 (0.33) | KMT2ASLC6A9MEN1PLD2PLD1 | |
| SCHEMBL5983573 | 0.82 | AURKA (0.37) | KMT2ALMNAPDPK1KDM4ENPC1 | |
| SCHEMBL4558093 | 0.79 | PLD2 (0.35) | KMT2AMEN1GAAPLD2PLD1 | |
| SCHEMBL4337663 | 0.78 | PDPK1 (0.43) | KMT2ALMNAMEN1PDPK1NPC1 | |
| SCHEMBL4328679 | 0.75 | PDPK1 (0.37) | KMT2ALMNAPDPK1KDM4ENPC1 | |
| SCHEMBL3946206 | 0.72 | KDM4E (0.42) | KMT2ALMNAMEN1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050153992-A1 | Pyrrolopyrimidine thion derivatives | TEIJIN PHARMA LIMITED (JP) | 2005-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050153992-A1 | Pyrrolopyrimidine thion derivatives | GSK3B, GSK3A, GSKIP | KMT2A 1753/4885LMNA 1696/4885SLC6A9 3739/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.