Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.46 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 5/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.43 |
| ▸ | PARP1 | P09874 | 4/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.38 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.36 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6450115 | 0.89 | MAP3K5 (0.47) | MKNK1MKNK2MAP3K5HTR1ASLC6A2 | |
| SCHEMBL5400478 | 0.87 | PARP10 (0.43) | MKNK1MKNK2HTR1AIP6K1PARP10 | |
| SCHEMBL5384472 | 0.87 | PARP10 (0.46) | MKNK1MKNK2HTR1AIP6K1PARP10 | |
| SCHEMBL6447882 | 0.83 | HTR1A (0.56) | MKNK1MKNK2MAP3K5HTR1ASLC6A2 | |
| SCHEMBL3123273 | 0.80 | SLC6A2 (0.56) | HTR1ASLC6A2SLC6A3SLC6A4HRH1 | |
| SCHEMBL28571503 | 0.78 | MKNK1 (0.46) | MKNK1MKNK2MAP3K5HTR1ASLC6A2 | |
| SCHEMBL6456150 | 0.76 | MKNK1 (0.58) | MKNK1MKNK2MAP3K5HTR1ASLC6A2 | |
| SCHEMBL6454967 | 0.73 | MKNK1 (0.49) | MKNK1MKNK2MAP3K5HTR1ASLC6A2 | |
| SCHEMBL6451281 | 0.73 | MKNK1 (0.58) | MKNK1MKNK2MAP3K5SLC6A4HRH1 | |
| SCHEMBL15566704 | 0.73 | MAP3K5 (0.54) | MKNK1MKNK2MAP3K5HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6964974-B2 | 2,3-oxidosqualene-lanosterol cyclase inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2005-11-15 | — | — | US | disclosed |