Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 10/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 10/20 | 0.56 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.52 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 6/20 | 0.45 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.45 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
| ▸ | NMT1 | P30419 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6450115 | 0.83 | MAP3K5 (0.47) | HTR1ASLC6A2SLC6A3SLC6A4MKNK1 | |
| SCHEMBL6447864 | 0.83 | MKNK1 (0.46) | HTR1ASLC6A2SLC6A3SLC6A4MKNK1 | |
| SCHEMBL29003883 | 0.82 | SLC6A2 (0.71) | HTR1ASLC6A2SLC6A3SLC6A4NMT1 | |
| SCHEMBL4233748 | 0.77 | MKNK1 (0.58) | HTR1ASLC6A2SLC6A3MKNK1MKNK2 | |
| SCHEMBL28571503 | 0.75 | MKNK1 (0.46) | HTR1ASLC6A2SLC6A4MKNK1MKNK2 | |
| SCHEMBL20563741 | 0.74 | ALB (0.46) | HTR1ASLC6A2SLC6A3SLC6A4 | |
| SCHEMBL6456150 | 0.73 | MKNK1 (0.58) | HTR1ASLC6A2SLC6A3MKNK1MKNK2 | |
| SCHEMBL6454967 | 0.73 | MKNK1 (0.49) | HTR1ASLC6A2SLC6A3MKNK1MKNK2 | |
| SCHEMBL5791812 | 0.72 | ALB (0.45) | HTR1ASLC6A2SLC6A3 | |
| SCHEMBL3123418 | 0.72 | SLC6A2 (0.68) | HTR1ASLC6A2SLC6A3SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6964974-B2 | 2,3-oxidosqualene-lanosterol cyclase inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2005-11-15 | — | — | US | disclosed |