Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.49 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.43 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.41 |
| ▸ | PARP3 | Q9Y6F1 | 2/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | TOP2A | P11388 | 3/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.38 |
| ▸ | BCL9 | O00512 | 1/20 | 0.37 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6456150 | 0.80 | MKNK1 (0.58) | MKNK1MKNK2MAP3K5HTR1ASLC6A2 | |
| SCHEMBL6447886 | 0.79 | OPRM1 (0.54) | MKNK1MKNK2MAP3K5HTR1ASLC6A2 | |
| SCHEMBL6454965 | 0.79 | PARP2 (0.49) | MKNK1MKNK2MAP3K5HTR1ASLC6A2 | |
| Hydrochloric Acid SCHEMBL31753763 | 0.77 | SCN9A (0.54) | ROCK2SCN9APARP1CHEK2 | |
| SCHEMBL6154865 | 0.75 | ROCK2 (0.72) | ROCK2PARP2PARP3PARP1 | |
| SCHEMBL4233748 | 0.75 | MKNK1 (0.58) | MKNK1MKNK2MAP3K5HTR1ASLC6A2 | |
| SCHEMBL6446339 | 0.74 | MKNK1 (0.58) | MKNK1MKNK2MAP3K5 | |
| SCHEMBL6451281 | 0.74 | MKNK1 (0.58) | MKNK1MKNK2MAP3K5TOP2AHSP90AB1 | |
| SCHEMBL17062481 | 0.74 | SCN9A (0.49) | HTR1ASLC6A2SLC6A3SCN9A | |
| SCHEMBL6447882 | 0.73 | HTR1A (0.56) | MKNK1MKNK2MAP3K5HTR1ASLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6964974-B2 | 2,3-oxidosqualene-lanosterol cyclase inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2005-11-15 | — | — | US | disclosed |