Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 10/20 | 0.54 |
| ▸ | CTSS | P25774 | 8/20 | 0.54 |
| ▸ | CTSB | P07858 | 8/20 | 0.54 |
| ▸ | CTSK | P43235 | 7/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CTSV | O60911 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6443785 | 0.89 | CTSL (0.44) | CTSLCTSSCTSBCTSKNPC1 | |
| SCHEMBL5526376 | 0.86 | EPHX2 (0.52) | CTSLCTSSCTSBCTSKNPC1 | |
| SCHEMBL6443960 | 0.85 | CTSB (0.44) | CTSLCTSSCTSBCTSKCTSV | |
| SCHEMBL5517733 | 0.85 | CTSL (0.51) | CTSLCTSSCTSBCTSKNPC1 | |
| SCHEMBL6446809 | 0.85 | KDM4E (0.51) | CTSLCTSSCTSBCTSK | |
| SCHEMBL6446731 | 0.84 | CACNA1B (0.46) | CTSLSMN1; SMN2 | |
| SCHEMBL6442984 | 0.84 | CTSL (0.49) | CTSLCTSSCTSBCTSKCTSV | |
| SCHEMBL5524114 | 0.84 | CTSL (0.56) | CTSLCTSSCTSBCTSKSMN1; SMN2 | |
| SCHEMBL6824499 | 0.83 | CTSL (0.62) | CTSLNPC1 | |
| SCHEMBL6442378 | 0.83 | GAA (0.47) | CTSLCTSSCTSBCTSKNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575903-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES | Jerini AG (DE) | 2005-09-21 | — | — | EP | claimed |
| WO-2004065353-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES | JERINI AG (DE) | 2004-08-05 | — | — | WO | claimed |
| WO-2004056755-A2 | COMPOUNDS FOR THE INHIBITION OF NON-PROTEOLYTIC ENZYMES | JERENI AG (DE) | 2004-07-08 | — | — | WO | claimed |
| EP-1575903-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES | Jerini AG (DE) | 2005-09-21 | — | — | EP | disclosed |
| WO-2004065353-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES | JERINI AG (DE) | 2004-08-05 | — | — | WO | disclosed |