Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.81 |
| ▸ | STAT3 | P40763 | 1/20 | 0.81 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.81 |
| ▸ | JAK2 | O60674 | 1/20 | 0.80 |
| ▸ | TYK2 | P29597 | 1/20 | 0.80 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.79 |
| ▸ | HTT | P42858 | 1/20 | 0.74 |
| ▸ | GAA | P10253 | 1/20 | 0.70 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.65 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.63 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.62 |
| ▸ | NAMPT | P43490 | 1/20 | 0.62 |
| ▸ | RAB9A | P51151 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.61 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30828578 | 0.91 | GAA (0.78) | POLBSTAT3SMN1; SMN2JAK2TYK2 | |
| SCHEMBL23734986 | 0.91 | GAA (0.85) | POLBSTAT3SMN1; SMN2JAK2TYK2 | |
| SCHEMBL30828573 | 0.91 | GAA (0.78) | POLBSTAT3SMN1; SMN2JAK2TYK2 | |
| SCHEMBL29013035 | 0.90 | POLB (1.00) | POLBSTAT3SMN1; SMN2JAK2TYK2 | |
| SCHEMBL19241697 | 0.89 | GAA (0.88) | POLBSTAT3SMN1; SMN2JAK2TYK2 | |
| SCHEMBL164882 | 0.89 | JAK2 (1.00) | POLBSTAT3SMN1; SMN2JAK2TYK2 | |
| SCHEMBL18085798 | 0.89 | PTPN1 (1.00) | POLBSTAT3SMN1; SMN2PTPN1KDM4E | |
| SCHEMBL23096186 | 0.87 | KDM4E (0.85) | POLBSTAT3SMN1; SMN2JAK2TYK2 | |
| SCHEMBL23760600 | 0.87 | KDM4E (0.85) | POLBSTAT3SMN1; SMN2JAK2TYK2 | |
| SCHEMBL27193241 | 0.87 | POLB (0.88) | POLBSTAT3SMN1; SMN2JAK2TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020183011-A1 | HTR1D INHIBITORS AND USES THEREOF IN THE TREATMENT OF CANCER | INSTITUT CURIE (FR) | 2020-09-17 | — | — | WO | disclosed |
| US-20050080084-A1 | Compositions of a cyclooxygenase-2 selective inhibitor and a serotonin-modulating agent for the treatment of central nervous system damage | PHARMACIA CORPORATION | 2005-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050080084-A1 | Compositions of a cyclooxygenase-2 selective inhibitor and a serotonin-modulating agent for the treatment of central nervous system damage | TPH2, TPH1, HTR2A | POLB 3014/4885STAT3 2673/4885SMN1; SMN2 337/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.