Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | TP53 | P04637 | 1/20 | 0.65 |
| ▸ | TACR3 | P29371 | 13/20 | 0.63 |
| ▸ | TACR2 | P21452 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.49 |
| ▸ | PTGFR | P43088 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6451528 | 0.93 | LMNA (0.66) | LMNATP53TACR3TACR2ALDH1A1 | |
| SCHEMBL6448599 | 0.87 | ALDH1A1 (0.67) | LMNATP53TACR3TACR2ALDH1A1 | |
| SCHEMBL6449830 | 0.87 | TACR3 (0.61) | LMNATP53TACR3TACR2ALDH1A1 | |
| SCHEMBL6448666 | 0.87 | TACR3 (0.60) | LMNATP53TACR3TACR2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL6449066 | 0.87 | TACR3 (0.62) | LMNATP53TACR3TACR2ALDH1A1 | |
| SCHEMBL6450548 | 0.83 | TACR3 (0.63) | LMNATP53TACR3TACR2ALDH1A1 | |
| SCHEMBL8619778 | 0.79 | TACR3 (0.63) | LMNATP53TACR3TACR2PDE10A | |
| SCHEMBL6448671 | 0.77 | TACR3 (1.00) | TP53TACR3TACR2ALDH1A1OPRM1 | |
| SCHEMBL6450716 | 0.77 | TACR3 (1.00) | TP53TACR3TACR2ALDH1A1OPRM1 | |
| SCHEMBL8226622 | 0.75 | ALDH1A1 (0.64) | LMNATP53TACR3TACR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1517708-A1 | COMBINATION TREATMENT FOR DEPRESSION AND ANXIETY BY NK1 AND NK3 ANTAGONISTS | Pfizer Products Inc. (US) | 2005-03-30 | — | — | EP | claimed |
| WO-2004000355-A1 | COMBINATION TREATMENT FOR DEPRESSION AND ANXIETY BY NK1 AND NK3 ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2003-12-31 | — | — | WO | claimed |
| EP-1517708-A1 | COMBINATION TREATMENT FOR DEPRESSION AND ANXIETY BY NK1 AND NK3 ANTAGONISTS | Pfizer Products Inc. (US) | 2005-03-30 | — | — | EP | disclosed |
| WO-2004000355-A1 | COMBINATION TREATMENT FOR DEPRESSION AND ANXIETY BY NK1 AND NK3 ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2003-12-31 | — | — | WO | disclosed |