Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR3 | P29371 | 11/20 | 0.60 |
| ▸ | TACR2 | P21452 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | TACR1 | P25103 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | DHODH | Q02127 | 4/20 | 0.58 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6449830 | 0.88 | TACR3 (0.61) | TACR3TACR2LMNACYP1A2CYP3A4 | |
| SCHEMBL6448599 | 0.88 | ALDH1A1 (0.67) | TACR3TACR2LMNACYP1A2CYP3A4 | |
| SCHEMBL6448792 | 0.87 | LMNA (0.65) | TACR3TACR2LMNAOPRM1TP53 | |
| SCHEMBL12564406 | 0.86 | DHODH (0.65) | TACR3TACR2LMNACYP1A2CYP3A4 | |
| SCHEMBL7033234 | 0.85 | LMNA (0.60) | TACR3TACR2LMNACYP1A2CYP3A4 | |
| SCHEMBL6451528 | 0.85 | LMNA (0.66) | TACR3TACR2LMNACYP1A2CYP3A4 | |
| SCHEMBL6450548 | 0.84 | TACR3 (0.63) | TACR3TACR2LMNACYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL6449066 | 0.83 | TACR3 (0.62) | TACR3TACR2LMNATACR1OPRM1 | |
| SCHEMBL4667328 | 0.77 | LMNA (0.53) | TACR3TACR2LMNACYP1A2CYP3A4 | |
| SCHEMBL3870523 | 0.76 | LMNA (0.65) | TACR3TACR2LMNACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1517708-A1 | COMBINATION TREATMENT FOR DEPRESSION AND ANXIETY BY NK1 AND NK3 ANTAGONISTS | Pfizer Products Inc. (US) | 2005-03-30 | — | — | EP | claimed |
| WO-2004000355-A1 | COMBINATION TREATMENT FOR DEPRESSION AND ANXIETY BY NK1 AND NK3 ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2003-12-31 | — | — | WO | claimed |
| EP-1289560-A1 | NOVEL SOLID DISPERSION COMPOSITIONS | SmithKline Beecham Corporation (US) | 2003-03-12 | — | — | EP | claimed |
| WO-2001095939-A1 | NOVEL SOLID DISPERSION COMPOSITIONS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-12-20 | — | — | WO | claimed |
| EP-1517708-A1 | COMBINATION TREATMENT FOR DEPRESSION AND ANXIETY BY NK1 AND NK3 ANTAGONISTS | Pfizer Products Inc. (US) | 2005-03-30 | — | — | EP | disclosed |
| WO-2004000355-A1 | COMBINATION TREATMENT FOR DEPRESSION AND ANXIETY BY NK1 AND NK3 ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2003-12-31 | — | — | WO | disclosed |
| EP-1289560-A1 | NOVEL SOLID DISPERSION COMPOSITIONS | SmithKline Beecham Corporation (US) | 2003-03-12 | — | — | EP | disclosed |
| WO-2001095939-A1 | NOVEL SOLID DISPERSION COMPOSITIONS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-12-20 | — | — | WO | disclosed |