SCHEMBL6449140

SCHEMBL6449140

COC[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCc1ccc(-c2ccccc2)c(C)c1)CC(=O)O)C(C)(C)C)c1ccccc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
MMP2 P08253 20/20 1.00
MMP3 P08254 12/20 1.00
MMP9 P14780 5/20 1.00
MMP14 P50281 5/20 1.00
MMP13 P45452 3/20 1.00
MMP1 P03956 3/20 0.87
BMP1 P13497 1/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6435957 0.93 MMP2 (1.00) MMP2MMP3MMP9MMP14MMP13
SCHEMBL7706922 0.92 MMP2 (0.85) MMP2MMP3MMP9MMP14MMP13
SCHEMBL7061522 0.91 MMP2 (0.83) MMP2MMP3MMP9MMP14MMP13
SCHEMBL7709927 0.91 MMP2 (0.83) MMP2MMP3MMP9MMP14MMP13
SCHEMBL6449143 0.91 MMP2 (0.83) MMP2MMP3MMP9MMP14MMP13
SCHEMBL7109428 0.90 MMP2 (0.82) MMP2MMP3MMP9MMP14MMP13
SCHEMBL7108052 0.89 MMP2 (0.79) MMP2MMP3MMP9MMP14MMP13
SCHEMBL7111094 0.88 MMP2 (0.79) MMP2MMP3MMP9MMP14MMP13
SCHEMBL7114064 0.87 MMP2 (0.85) MMP2MMP3MMP9MMP14MMP13
SCHEMBL6436785 0.87 MMP2 (0.85) MMP2MMP3MMP9MMP14MMP13

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4744663-A2 SKIN COMPOSITION Eaderm Co., Ltd. (JP) 2026-05-20 EP claimed
US-20220331389-A1 SKIN COMPOSITION EADERM CO., LTD. (JP) 2022-10-20 US claimed
US-11298372-B2 Composition for ameliorating loss of hair and graying of hair, and use thereof NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY (JP) 2022-04-12 US claimed
EP-3978020-A1 SKIN COMPOSITION National University Corporation Tokyo Medical and Dental University (JP) 2022-04-06 EP claimed
EP-1047665-B1 MATRIX METALLOPROTEASE INHIBITORS PFIZER LTD (GB) 2003-10-22 EP claimed
US-20030099693-A1 Wafer PFIZER INC. 2003-05-29 US claimed
WO-2003037395-A1 WAFER FOR WOUNDS PFIZER LIMITED (GB) 2003-05-08 WO claimed
US-6350907-B1 PEPTIDE ENZYME INHIBITORS PFIZER INC 2002-02-26 US claimed
EP-4744663-A2 SKIN COMPOSITION Eaderm Co., Ltd. (JP) 2026-05-20 EP disclosed
US-20250228875-A1 METHODS OF TREATING, AMELIORATING AND/OR PREVENTING FIBRODYSPLASIA OSSIFICANS PROGRESSIVA AND HETEROTOPIC OSSIFICATION, AND KITS FOR THE SAME THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA 2025-07-17 US disclosed
WO-2025076396-A1 METHODS OF TREATING, AMELIORATING AND/OR PREVENTING FIBRODYSPLASIA OSSIFICANS PROGRESSIVA AND HETEROTOPIC OSSIFICATION, AND KITS FOR THE SAME THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2025-04-10 WO disclosed
EP-4205750-B1 NADPH OXIDASE INHIBITOR FOR SUPPRESSING OR IMPROVING HAIR LOSS OR TREATING ALOPECIA EADERM CO LTD (JP) 2025-04-09 EP disclosed
EP-4499131-A2 METHODS OF TREATING, AMELIORATING AND/OR PREVENTING FIBRODYSPLASIA OSSIFICANS PROGRESSIVA AND HETEROTOPIC OSSIFICATION, AND KITS FOR THE SAME The Trustees of The University of Pennsylvania (US) 2025-02-05 EP disclosed
CN-119365210-A Methods and kits for treating, ameliorating and/or preventing progressive ossified fibrous tissue dysplasia and ectopic ossification 宾夕法尼亚大学董事会 2025-01-24 CN disclosed
US-20140178293-A1 METHODS FOR IMAGING BONE PRECURSOR CELLS USING DUAL-LABELED IMAGING AGENTS TO DETECT MMP-9 POSITIVE CELLS BAYLOR COLLEGE OF MEDICINE (US) 2014-06-26 US disclosed
US-20050026836-A1 Composition for the treatment of damaged tissue DACK KEVIN NEIL (GB) 2005-02-03 US disclosed
EP-1047665-B1 MATRIX METALLOPROTEASE INHIBITORS PFIZER LTD (GB) 2003-10-22 EP disclosed
US-20030099693-A1 Wafer PFIZER INC. 2003-05-29 US disclosed
WO-2003037395-A1 WAFER FOR WOUNDS PFIZER LIMITED (GB) 2003-05-08 WO disclosed
US-6350907-B1 PEPTIDE ENZYME INHIBITORS PFIZER INC 2002-02-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050026836-A1 Composition for the treatment of damaged tissue MMP1, SERPINE1, COL14A1 MMP2 19/4885MMP3 28/4885MMP9 44/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.