Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 1/20 | 0.67 |
| ▸ | THRB | P10828 | 17/20 | 0.55 |
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | VDR | P11473 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | PPARG | P37231 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6450193 | 0.88 | VCAM1 (0.59) | VCAM1THRBPOLBMEN1KMT2A | |
| SCHEMBL7357430 | 0.79 | HPGD (0.64) | VCAM1POLBMAPTHTTMEN1 | |
| SCHEMBL3530451 | 0.76 | VCAM1 (0.71) | VCAM1THRBPOLBMEN1KMT2A | |
| SCHEMBL3866808 | 0.74 | APEX1 (0.66) | POLBMAPTMEN1KMT2ALMNA | |
| SCHEMBL5095095 | 0.73 | VCAM1 (0.67) | VCAM1THRBPOLBMAPTHTT | |
| SCHEMBL9731903 | 0.73 | MAPT (0.50) | VCAM1POLBMAPTHTTMEN1 | |
| SCHEMBL20857019 | 0.73 | PARP1 (0.59) | POLBMAPTHTTMEN1KMT2A | |
| SCHEMBL16955575 | 0.72 | MAPT (0.56) | VCAM1POLBMAPTHTTMEN1 | |
| SCHEMBL7895159 | 0.70 | APEX1 (0.53) | POLBMAPTMEN1KMT2ALMNA | |
| SCHEMBL19071961 | 0.70 | VCAM1 (0.79) | VCAM1THRBPOLBMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1565446-A1 | CHK-, PDK- AND AKT-INHIBITORY PYRIMIDINES, THEIR PRODUCTION AND USE AS PHARMACEUTICAL AGENTS | SCHERING AKTIENGESELLSCHAFT (DE) | 2005-08-24 | — | — | EP | disclosed |
| WO-2004048343-A1 | CHK-, PDK- AND AKT-INHIBITORY PYRIMIDINES, THEIR PRODUCTION AND USE AS PHARMACEUTICAL AGENTS | SCHERING AKTIENGESELLSCHAFT (DE) | 2004-06-10 | — | — | WO | disclosed |