Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 5/20 | 0.50 |
| ▸ | CES2 | O00748 | 4/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | DAO | P14920 | 1/20 | 0.50 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.50 |
| ▸ | AKT1 | P31749 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | CA4 | P22748 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | CA12 | O43570 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA9 | Q16790 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7464184 | 0.78 | CES1 (0.55) | CES1CES2TSHRALDH1A1DAO | |
| SCHEMBL5143659 | 0.78 | HSP90AA1 (0.57) | CES1CES2TSHRALDH1A1DAO | |
| SCHEMBL10413479 | 0.78 | CES1 (0.55) | CES1CES2TSHRALDH1A1DAO | |
| SCHEMBL10363774 | 0.77 | MAPT (0.52) | CES2ALDH1A1TDP1CYP3A4MAPT | |
| SCHEMBL9169521 | 0.76 | CES1 (0.52) | CES1CES2TSHRALDH1A1DAO | |
| SCHEMBL144974 | 0.76 | CES1 (0.52) | CES1CES2TSHRALDH1A1DAO | |
| Benzoic Acid SCHEMBL28174048 | 0.76 | TSHR (0.78) | CES1CES2TSHRALDH1A1DAO | |
| SCHEMBL1224121 | 0.75 | CES2 (0.54) | CES1CES2TSHRALDH1A1CYP3A4 | |
| SCHEMBL10455142 | 0.74 | CES1 (0.50) | CES1CES2TSHRALDH1A1DAO | |
| SCHEMBL139423 | 0.74 | CES1 (0.50) | CES1CES2TSHRALDH1A1DAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 253 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3004066-B1 | PROCESS FOR PREPARING 4,6-BIS(ARYLOXY)PYRIMIDINE DERIVATIVES | CHEMINOVA AS (DK) | 2018-04-11 | — | — | EP | claimed |
| CN-105246878-B | The method for preparing 4,6 pairs of (aryloxy group) pyrimidine derivatives | 切米诺瓦有限公司 | 2017-12-15 | — | — | CN | claimed |
| US-9643935-B2 | Process for preparing 4,6-BIS (aryloxy) pyrimidine derivatives | CHEMINOVA A/S (DK) | 2017-05-09 | — | — | US | claimed |
| EP-2640706-B1 | N-ARYL PYRAZOLE(THIO)CARBOXAMIDES | BAYER IP GMBH (DE) | 2017-03-01 | — | — | EP | claimed |
| US-20160137612-A1 | PROCESS FOR PREPARING 4,6-BIS (ARYLOXY) PYRIMIDINE DERIVATIVES | CHEMINOVA A/S (DK) | 2016-05-19 | — | — | US | claimed |
| EP-3004066-A1 | PROCESS FOR PREPARING 4,6-BIS(ARYLOXY)PYRIMIDINE DERIVATIVES | Cheminova A/S (DK) | 2016-04-13 | — | — | EP | claimed |
| CN-105246878-A | Process for preparing 4,6-bis(aryloxy)pyrimidine derivatives | CHEMINOVA AS | 2016-01-13 | — | — | CN | claimed |
| US-9206137-B2 | N-Aryl pyrazole(thio)carboxamides | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-12-08 | — | — | US | claimed |
| US-20150294752-A1 | GRAPHENE MASTERBATCH | ENERAGE INC. (TW) | 2015-10-15 | — | — | US | claimed |
| EP-1713789-B1 | 2-HALOFURYL/THIENYL-3-CARBOXAMIDES | BAYER IP GMBH (DE) | 2015-05-27 | — | — | EP | claimed |
| EP-0937050-A1 | HALOGEN PYRIMIDINYL ARYL (THIO)ETHERS AS PESTICIDES | BAYER AG (DE) | 1999-08-25 | — | — | EP | claimed |
| CN-1209808-A | Halogenated pyrimidines and their use as a method for reducing parasites | BAYER AG (DE) | 1999-03-03 | — | — | CN | claimed |
| EP-0882043-A1 | HALOGEN PYRIMIDINES AND ITS USE THEREOF AS PARASITE ABATEMENT MEANS | BAYER AG (DE) | 1998-12-09 | — | — | EP | claimed |
| WO-1998021189-A1 | HALOGEN PYRIMIDINYL ARYL (THIO)ETHERS AS PESTICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 1998-05-22 | — | — | WO | claimed |
| WO-1997027189-A1 | HALOGEN PYRIMIDINES AND ITS USE THEREOF AS PARASITE ABATEMENT MEANS | BAYER AKTIENGESELLSCHAFT (DE) | 1997-07-31 | — | — | WO | claimed |
| WO-1993012079-A1 | NOVEL PHENYLSULFONYLACRYLATE ESTER DERIVATIVES | RICHTER GEDEON VEGYE^´SZETI GYÁR RT. (HU) | 1993-06-24 | — | — | WO | claimed |
| EP-0232849-B1 | PYRROLIDINEAMIDE DERIVATIVE OF ACYLAMINO ACID, PHARMACEUTICAL COMPOSITION AND USE | SUNTORY LIMITED (JP) | 1993-05-05 | — | — | EP | claimed |
| US-4826870-A | CURING AMNESIA | SUNTORY LIMITED (JP) | 1989-05-02 | — | — | US | claimed |
| EP-0232849-A2 | Pyrrolidineamide derivative of acylamino acid, pharmaceutical composition and use | SUNTORY LIMITED (JP) | 1987-08-19 | — | — | EP | claimed |
| US-4433152-A | ANTIINFLAMMATORY AGENT, ANTIALLERGEN OR ANTICOAGULANT | NIPPON CHEMIPHAR CO., LTD. (JP) | 1984-02-21 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160137612-A1 | PROCESS FOR PREPARING 4,6-BIS (ARYLOXY) PYRIMIDINE DERIVATIVES | NUDT1, UMPS, DPYD | CES1 1711/4885CES2 1302/4885TSHR 2285/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.