Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK1 | P06870 | 4/20 | 0.38 |
| ▸ | KLK5 | Q9Y337 | 4/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.38 |
| ▸ | F2 | P00734 | 4/20 | 0.37 |
| ▸ | F9 | P00740 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 5/20 | 0.37 |
| ▸ | PLG | P00747 | 5/20 | 0.37 |
| ▸ | PLAU | P00749 | 5/20 | 0.37 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.34 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.34 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6450643 | 0.93 | F2 (0.40) | KLK1KLK5ITGB3ITGA2BF2 | |
| SCHEMBL6462435 | 0.86 | ITGB3 (0.43) | KLK1KLK5ITGB3ITGA2BF2 | |
| SCHEMBL6455724 | 0.84 | F2 (0.39) | KLK1KLK5F2F9F10 | |
| SCHEMBL6457229 | 0.80 | F2 (0.41) | KLK1KLK5ITGB3ITGA2BF2 | |
| SCHEMBL7450241 | 0.79 | F2 (0.57) | KLK1KLK5ITGB3ITGA2BF2 | |
| SCHEMBL6451890 | 0.75 | F2 (0.60) | KLK1KLK5F2F9F10 | |
| SCHEMBL7453719 | 0.71 | F2 (0.42) | KLK1KLK5ITGB3ITGA2BF2 | |
| SCHEMBL6455654 | 0.70 | F2 (0.46) | KLK1KLK5ITGB3ITGA2BF2 | |
| SCHEMBL7442317 | 0.70 | F2 (0.54) | KLK1KLK5ITGB3ITGA2BF2 | |
| SCHEMBL7348645 | 0.69 | ITGB3 (0.56) | KLK1KLK5ITGB3ITGA2BF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1517687-A1 | MEDICAMENT FOR THE TREATMENT OF THE SYSTEMIC INFLAMMATORY RESPONSE SYNDROME | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2005-03-30 | — | — | EP | disclosed |
| WO-2004000310-A1 | MEDICAMENT FOR THE TREATMENT OF THE SYSTEMIC INFLAMMATORY RESPONSE SYNDROME | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2003-12-31 | — | — | WO | disclosed |