Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.57 |
| ▸ | MMP12 | P39900 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | MLYCD | O95822 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6452267 | 0.88 | MMP12 (0.68) | HDAC6HDAC4MMP12HDAC3HDAC1 | |
| SCHEMBL6874296 | 0.88 | MMP12 (0.68) | HDAC6HDAC4MMP12HDAC3HDAC1 | |
| SCHEMBL6457597 | 0.86 | HDAC4 (0.56) | HDAC6HDAC4MMP12MEN1KMT2A | |
| SCHEMBL6878595 | 0.83 | MMP12 (0.55) | HDAC6HDAC4MMP12MEN1KMT2A | |
| SCHEMBL6878598 | 0.83 | MMP12 (0.55) | HDAC6HDAC4MMP12MEN1KMT2A | |
| SCHEMBL6371105 | 0.80 | MMP12 (0.80) | HDAC6HDAC4MMP12MEN1KMT2A | |
| SCHEMBL6451716 | 0.79 | MMP12 (0.81) | HDAC6HDAC4MMP12MMP13HDAC3 | |
| SCHEMBL8340443 | 0.77 | MMP12 (0.55) | HDAC6HDAC4MMP12MMP13MAPK14 | |
| SCHEMBL6456462 | 0.74 | MMP12 (0.72) | HDAC6HDAC4MMP12MEN1KMT2A | |
| SCHEMBL6455095 | 0.74 | MMP12 (0.71) | HDAC6HDAC4MMP12MMP13HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534700-A1 | NOVEL THIOPHENE DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | WARNER-LAMBERT COMPANY LLC (US) | 2005-06-01 | — | — | EP | disclosed |
| WO-2004018448-A1 | NOVEL THIOPHENE DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | WARNER-LAMBERT COMPANY LLC (US) | 2004-03-04 | — | — | WO | disclosed |