Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 3/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.56 |
| ▸ | MMP12 | P39900 | 5/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | MMP13 | P45452 | 2/20 | 0.47 |
| ▸ | MMP3 | P08254 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | PLK4 | O00444 | 1/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8340443 | 0.88 | MMP12 (0.55) | HDAC4HDAC6MMP12ROCK2ROCK1 | |
| SCHEMBL6455095 | 0.87 | MMP12 (0.71) | HDAC4HDAC6MMP12ROCK2MMP13 | |
| Hydrochloric Acid SCHEMBL6881474 | 0.86 | MMP12 (0.70) | HDAC4HDAC6MMP12ROCK2MMP13 | |
| SCHEMBL6450858 | 0.86 | HDAC6 (0.57) | HDAC4HDAC6MMP12ROCK2ROCK1 | |
| SCHEMBL6882247 | 0.82 | MMP12 (0.56) | HDAC4HDAC6MMP12ROCK2MEN1 | |
| SCHEMBL6451716 | 0.81 | MMP12 (0.81) | HDAC4HDAC6MMP12MMP13MMP8 | |
| SCHEMBL26856930 | 0.77 | PIK3CG (0.47) | HDAC4HDAC6MMP12MEN1KMT2A | |
| SCHEMBL6456462 | 0.76 | MMP12 (0.72) | HDAC4HDAC6MMP12MEN1KMT2A | |
| SCHEMBL26856937 | 0.76 | PIK3CG (0.48) | HDAC4HDAC6MMP12HDAC3HDAC1 | |
| SCHEMBL6463535 | 0.75 | MMP12 (0.88) | HDAC4HDAC6MMP12MMP13MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534700-A1 | NOVEL THIOPHENE DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | WARNER-LAMBERT COMPANY LLC (US) | 2005-06-01 | — | — | EP | claimed |
| WO-2004018448-A1 | NOVEL THIOPHENE DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | WARNER-LAMBERT COMPANY LLC (US) | 2004-03-04 | — | — | WO | claimed |