SCHEMBL6453422

SCHEMBL6453422

O=C1OC(CO)CN1c1ccc(N2CCN(Cc3ccccc3)CC2)c(F)c1

nearest known ligand 0.56

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
CALML3 P27482 5/20 0.56
MAOB P27338 10/20 0.52
MAOA P21397 4/20 0.52
LMNA P02545 1/20 0.52
PTGS1 P23219 1/20 0.52
SDHA P31040 1/20 0.52
F10 P00742 6/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13404013 0.90 MAOB (0.49) CALML3MAOBMAOALMNAPTGS1
SCHEMBL28110345 0.89 MAOB (0.58) CALML3MAOBMAOALMNAPTGS1
SCHEMBL28428084 0.89 MAOB (0.58) CALML3MAOBMAOALMNAPTGS1
SCHEMBL6525428 0.86 MAOA (0.73) CALML3MAOBMAOALMNAPTGS1
SCHEMBL29196827 0.85 CALML3 (0.55) CALML3MAOBMAOALMNAPTGS1
SCHEMBL29196830 0.85 CALML3 (0.55) CALML3MAOBMAOALMNAPTGS1
SCHEMBL14580096 0.84 CALML3 (0.57) CALML3MAOBMAOALMNAPTGS1
SCHEMBL28109794 0.84 CALML3 (0.65) CALML3MAOBMAOALMNAPTGS1
SCHEMBL14898018 0.84 CALML3 (0.61) CALML3MAOBMAOALMNAPTGS1
SCHEMBL7493173 0.83 MAOB (0.62) CALML3MAOBMAOALMNAPTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050118624-A1 Fluorescent probes for ribosomes and method of use CUMBRE INC. (US) 2005-06-02 US disclosed
WO-2005036169-A2 FLUORESCENT PROBES FOR RIBOSOMES AND METHOD OF USE CUMBRE INC. (US) 2005-04-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050118624-A1 Fluorescent probes for ribosomes and method of use MRPS27, NOP2, RPL30 CALML3 2280/4885MAOB 4549/4885MAOA 4599/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.