Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6455331 | 0.92 | THRA (0.39) | THRAKMT2AKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL6455618 | 0.73 | THRA (0.42) | THRAKMT2AKDM4EL3MBTL1THRB | |
| SCHEMBL5762275 | 0.73 | KDM4E (0.43) | KMT2AKDM4EALDH1A1MEN1THRB | |
| SCHEMBL6462050 | 0.73 | P2RX7 (0.41) | THRAKMT2AKDM4EALDH1A1MEN1 | |
| SCHEMBL6475079 | 0.72 | THRA (0.34) | THRAKMT2AKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL6454982 | 0.72 | THRA (0.42) | THRAKMT2AL3MBTL1MEN1THRB | |
| SCHEMBL6453803 | 0.71 | P2RX7 (0.39) | THRAKMT2AMEN1THRB | |
| SCHEMBL6455333 | 0.71 | P2RX7 (0.42) | THRAKMT2AMEN1THRB | |
| SCHEMBL7142482 | 0.70 | P2RX7 (0.38) | THRAKMT2AMEN1THRB | |
| SCHEMBL6459750 | 0.69 | P2RX7 (0.41) | THRAKMT2AMEN1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6894046-B2 | IL-5 inhibiting 6-azauracil derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-05-17 | — | — | US | disclosed |
| EP-1114046-B1 | INTERLEUKIN-5 INHIBITING 6-AZAURACIL DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2003-04-23 | — | — | EP | disclosed |
| EP-1114046-A1 | INTERLEUKIN-5 INHIBITING 6-AZAURACIL DERIVATIVES | Janssen Pharmaceutica N.V. (BE) | 2001-07-11 | — | — | EP | disclosed |
| WO-2000017195-A1 | INTERLEUKIN-5 INHIBITING 6-AZAURACIL DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2000-03-30 | — | — | WO | disclosed |
| EP-0987265-A1 | Interleukin-5 inhibiting 6-azauracil derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2000-03-22 | — | — | EP | disclosed |