SCHEMBL6454517

SCHEMBL6454517

CC(=O)c1ccc(CS(=O)(=O)O)n1C.O=C(c1ccccc1)c1cccc(CCS(=O)(=O)O)c1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 2/20 0.36
L3MBTL1 Q9Y468 2/20 0.35
ATM Q13315 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
ALDH1A1 P00352 2/20 0.35
GLA P06280 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
MAPK14 Q16539 2/20 0.35
KAT6A Q92794 1/20 0.34
PTGS1 P23219 2/20 0.34
PTGS2 P35354 2/20 0.34
CXCL8 P10145 1/20 0.34
AKR1B1 P15121 1/20 0.34
GLO1 Q04760 1/20 0.34
HDAC3 O15379 1/20 0.33
HDAC4 P56524 1/20 0.33
HDAC1 Q13547 1/20 0.33
HDAC7 Q8WUI4 1/20 0.33
HDAC2 Q92769 1/20 0.33
HDAC10 Q969S8 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL688533 0.81 L3MBTL1 (0.53) CYP19A1L3MBTL1ATMTDP1ALDH1A1
SCHEMBL687746 0.80 L3MBTL1 (0.52) CYP19A1L3MBTL1ATMTDP1ALDH1A1
SCHEMBL688830 0.76 CXCL8 (0.36) ALDH1A1PTGS1PTGS2CXCL8AKR1B1
SCHEMBL6471185 0.74 PTGS1 (0.48) L3MBTL1ATMTDP1ALDH1A1SMN1; SMN2
SCHEMBL29108703 0.69 FOLH1 (0.54)
SCHEMBL6454767 0.69 L3MBTL1 (0.47) CYP19A1L3MBTL1ATMTDP1MAPK14
SCHEMBL29001417 0.69 MEN1 (0.50) L3MBTL1ATMTDP1ALDH1A1SMN1; SMN2
SCHEMBL687745 0.69 ATM (0.50) CYP19A1L3MBTL1ATMTDP1ALDH1A1
SCHEMBL8729453 0.67 CXCL8 (0.51) ALDH1A1KAT6APTGS1PTGS2CXCL8
SCHEMBL11138073 0.67 ALDH1A1 (0.65) CYP19A1L3MBTL1ATMTDP1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1606248-A2 SULFONIC ACIDS, THEIR DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Dompé S.P.A. (IT) 2005-12-21 EP claimed
WO-2004080951-A2 SULFONIC ACIDS, THEIR DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM DOMPE S.P.A. (IT) 2004-09-23 WO claimed