Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 5/20 | 0.74 |
| ▸ | MMP12 | P39900 | 4/20 | 0.74 |
| ▸ | MMP2 | P08253 | 2/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4440716 | 0.93 | MMP12 (0.81) | MMP13MMP12MMP2 | |
| SCHEMBL4440725 | 0.93 | MMP12 (0.81) | MMP13MMP12MMP2 | |
| SCHEMBL4057642 | 0.87 | MMP12 (0.70) | MMP13MMP12MMP2 | |
| SCHEMBL4057638 | 0.87 | MMP12 (0.70) | MMP13MMP12MMP2 | |
| SCHEMBL4056765 | 0.86 | MMP2 (0.76) | MMP13MMP2 | |
| SCHEMBL4556619 | 0.86 | MMP2 (0.76) | MMP13MMP2 | |
| SCHEMBL4056772 | 0.86 | MMP2 (0.76) | MMP13MMP2 | |
| SCHEMBL6675782 | 0.86 | MMP12 (0.69) | MMP13MMP12MMP2 | |
| SCHEMBL4056790 | 0.86 | MMP12 (0.69) | MMP13MMP12MMP2 | |
| SCHEMBL4056797 | 0.86 | MMP12 (0.69) | MMP13MMP12MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6906053-B2 | Hydantoins and related heterocycles as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE) | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2005-06-14 | — | — | US | claimed |