Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 4/20 | 0.49 |
| ▸ | HTR1A | P08908 | 2/20 | 0.49 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.43 |
| ▸ | CCR1 | P32246 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.41 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 4/20 | 0.40 |
| ▸ | HTR2A | P28223 | 3/20 | 0.40 |
| ▸ | DRD3 | P35462 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | SSTR5 | P35346 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6455344 | 0.83 | HTR7 (0.52) | HTR7HTR1ASLC6A5MCHR1SLC6A12 | |
| SCHEMBL6466592 | 0.83 | HTR7 (0.55) | HTR7HTR1ASLC6A5MCHR1SLC6A12 | |
| SCHEMBL6462598 | 0.82 | HTR7 (0.54) | HTR7HTR1ASLC6A5MCHR1SLC6A12 | |
| SCHEMBL6458101 | 0.82 | HTR7 (0.54) | HTR7HTR1ASLC6A5MCHR1SLC6A12 | |
| SCHEMBL6457855 | 0.80 | HTR7 (0.53) | HTR7HTR1ASLC6A5MCHR1SLC6A12 | |
| SCHEMBL6823762 | 0.80 | HTR2A (0.45) | HTR7HTR1AMCHR1DRD2HTR2A | |
| SCHEMBL6457221 | 0.78 | HTR7 (0.55) | HTR7HTR1AMCHR1SLC6A12TMEM97 | |
| SCHEMBL6820570 | 0.78 | UTS2R (0.42) | HTR7HTR1ADRD2HTR2APOLB | |
| SCHEMBL6462987 | 0.77 | HTR7 (0.47) | HTR7HTR1APOLB | |
| SCHEMBL6823893 | 0.77 | HTR7 (0.45) | HTR7HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1012147-B1 | O-SUBSTITUTED HYDROXYCUMARANONE DERIVATIVES AS ANTITUMOR AND ANTIMETASTATIC AGENTS | HOFFMANN LA ROCHE (CH) | 2005-11-02 | — | — | EP | disclosed |
| US-6200989-B1 | ADMINISTERING AS UROKINASE PLASMINOGEN ACTIVATOR ANTAGONISTS, ANTITUMOR AND ANTIMETASTASIS AGENTS | HOFFMANN-LA ROCHE INC. | 2001-03-13 | — | — | US | disclosed |