Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 7/20 | 0.54 |
| ▸ | HTR1A | P08908 | 4/20 | 0.54 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.45 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.45 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 5/20 | 0.44 |
| ▸ | HTR2A | P28223 | 4/20 | 0.44 |
| ▸ | DRD3 | P35462 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6462598 | 1.00 | HTR7 (0.54) | HTR7HTR1AMCHR1SLC6A12TMEM97 | |
| SCHEMBL6466592 | 0.97 | HTR7 (0.55) | HTR7HTR1AMCHR1SLC6A12TMEM97 | |
| SCHEMBL6457221 | 0.94 | HTR7 (0.55) | HTR7HTR1AMCHR1SLC6A12TMEM97 | |
| SCHEMBL7347807 | 0.92 | HTR7 (0.53) | HTR7HTR1AMCHR1SLC6A12TMEM97 | |
| SCHEMBL6457611 | 0.92 | SLC6A5 (0.51) | HTR7HTR1ADRD2HTR2ADRD3 | |
| SCHEMBL6462987 | 0.91 | HTR7 (0.47) | HTR7HTR1APOLBADRA1DADRA1A | |
| SCHEMBL6457124 | 0.91 | ADRA1D (0.50) | HTR7HTR1ADRD2HTR2ADRD3 | |
| SCHEMBL6461236 | 0.90 | HTR7 (0.46) | HTR7HTR1APOLBADRA1DADRA1A | |
| SCHEMBL6463130 | 0.89 | POLB (0.51) | HTR7HTR1AHTR2ADRD3POLB | |
| SCHEMBL6467624 | 0.88 | HRH2 (0.55) | HTR7HTR1ADRD2HTR2ADRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1012147-B1 | O-SUBSTITUTED HYDROXYCUMARANONE DERIVATIVES AS ANTITUMOR AND ANTIMETASTATIC AGENTS | HOFFMANN LA ROCHE (CH) | 2005-11-02 | — | — | EP | disclosed |
| US-6200989-B1 | ADMINISTERING AS UROKINASE PLASMINOGEN ACTIVATOR ANTAGONISTS, ANTITUMOR AND ANTIMETASTASIS AGENTS | HOFFMANN-LA ROCHE INC. | 2001-03-13 | — | — | US | disclosed |