Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 6/20 | 0.45 |
| ▸ | DRD3 | P35462 | 6/20 | 0.45 |
| ▸ | DRD2 | P14416 | 5/20 | 0.45 |
| ▸ | HTR7 | P34969 | 4/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | UBE2N | P61088 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6820569 | 0.92 | HTR7 (0.55) | HTR7HTR1AMCHR1DRD4 | |
| SCHEMBL6823928 | 0.92 | HTR7 (0.55) | HTR7HTR1AMCHR1DRD4 | |
| SCHEMBL6823394 | 0.92 | HTR7 (0.45) | HTR7HTR1ADRD4MEN1KMT2A | |
| SCHEMBL6823555 | 0.92 | HTR7 (0.45) | HTR7HTR1ADRD4MEN1KMT2A | |
| SCHEMBL6823893 | 0.92 | HTR7 (0.45) | HTR7HTR1ADRD4MEN1KMT2A | |
| SCHEMBL6824327 | 0.88 | HTR7 (0.42) | HTR2ADRD2HTR7HTR1ADRD4 | |
| SCHEMBL6824547 | 0.88 | HTR7 (0.42) | HTR2ADRD2HTR7HTR1ADRD4 | |
| SCHEMBL6823876 | 0.83 | HTR7 (0.46) | HTR2ADRD3DRD2HTR7HTR1A | |
| SCHEMBL6823760 | 0.82 | HTR7 (0.45) | HTR2ADRD3DRD2HTR7HTR1A | |
| SCHEMBL6455348 | 0.80 | HTR7 (0.49) | HTR2ADRD3DRD2HTR7HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004076444-A2 | NOVEL HYDROXYCOUMARANONE DERIVATIVES AS ANTITUMOR AND ANTIMETASTATIC | F. HOFFMANN-LA ROCHE AG (CH) | 2004-09-10 | — | — | WO | claimed |
| WO-2004076444-A2 | NOVEL HYDROXYCOUMARANONE DERIVATIVES AS ANTITUMOR AND ANTIMETASTATIC | F. HOFFMANN-LA ROCHE AG (CH) | 2004-09-10 | — | — | WO | disclosed |