Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.59 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.59 |
| ▸ | RPA1 | P27694 | 2/20 | 0.59 |
| ▸ | FABP3 | P05413 | 1/20 | 0.54 |
| ▸ | FABP4 | P15090 | 1/20 | 0.54 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | CDK1 | P06493 | 1/20 | 0.50 |
| ▸ | CDK4 | P11802 | 1/20 | 0.50 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28873587 | 0.98 | RPA1 (0.61) | ALDH1A1LMNAHTTPTGS2PTGS1 | |
| SCHEMBL11391264 | 0.94 | RPA1 (0.67) | ALDH1A1LMNAHTTPTGS2PTGS1 | |
| SCHEMBL15452759 | 0.93 | PTGS2 (0.69) | ALDH1A1LMNAHTTPTGS2PTGS1 | |
| SCHEMBL5214995 | 0.92 | PTGS2 (0.67) | PTGS2PTGS1RPA1FABP3FABP4 | |
| SCHEMBL13029788 | 0.86 | RAB9A (0.53) | ALDH1A1PTGS1RPA1FABP3FABP4 | |
| SCHEMBL3852411 | 0.85 | RAB9A (0.62) | ALDH1A1LMNAHTTPTGS1RPA1 | |
| SCHEMBL8291470 | 0.85 | PTGS2 (0.68) | ALDH1A1LMNAPTGS2PTGS1RPA1 | |
| SCHEMBL29505126 | 0.85 | ALDH1A1 (0.55) | ALDH1A1LMNAHTTPTGS2PTGS1 | |
| SCHEMBL15714178 | 0.85 | ALDH1A1 (0.60) | ALDH1A1LMNAHTTPTGS2PTGS1 | |
| SCHEMBL13166592 | 0.85 | ALDH1A1 (0.63) | ALDH1A1LMNAHTTPTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050130971-A1 | Compositions of a cyclooxygenase-2 selective inhibitor and phosphodiesterase inhibitor for the treatment of ischemic mediated central nervous system disorders or injury | PHARMACIA CORPORATION | 2005-06-16 | — | — | US | disclosed |
| WO-2000019994-A1 | ESTROGEN RECEPTOR LIGANDS | BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2000-04-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050130971-A1 | Compositions of a cyclooxygenase-2 selective inhibitor and phosphodiesterase inhibitor for the treatment of ischemic mediated central nervous system disorders or injury | PDE2A, PDE3B, PDE3A | ALDH1A1 845/4885LMNA 2444/4885HTT 3758/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.