Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.48 |
| ▸ | CCNC | P24863 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4262298 | 0.94 | NPC1 (0.58) | NPC1RAB9AMAPTKMT2AMEN1 | |
| SCHEMBL4262302 | 0.94 | NPC1 (0.58) | NPC1RAB9AMAPTKMT2AMEN1 | |
| Trifluoroacetic Acid SCHEMBL4260895 | 0.83 | MCHR1 (0.41) | NPC1RAB9AKMT2AMEN1MCHR1 | |
| Trifluoroacetic Acid SCHEMBL5670205 | 0.83 | MCHR1 (0.41) | NPC1RAB9AKMT2AMEN1MCHR1 | |
| Trifluoroacetic Acid SCHEMBL6457766 | 0.82 | NPC1 (0.52) | NPC1RAB9AMAPTKMT2AMEN1 | |
| SCHEMBL4257938 | 0.82 | MCHR1 (0.42) | NPC1RAB9AMAPTKMT2AMEN1 | |
| Trifluoroacetic Acid SCHEMBL6459529 | 0.81 | NPC1 (0.51) | NPC1RAB9AMAPTKMT2AMEN1 | |
| SCHEMBL4263684 | 0.81 | SMN1; SMN2 (0.50) | NPC1RAB9AMAPTKMT2AMEN1 | |
| SCHEMBL4263695 | 0.81 | SMN1; SMN2 (0.50) | NPC1RAB9AMAPTKMT2AMEN1 | |
| SCHEMBL4263678 | 0.80 | MCHR1 (0.73) | NPC1RAB9AMCHR1CNR1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090036448-A1 | PYRIMIDINE DERIVATIVES AND METHODS OF TREATMENT RELATED TO THE USE THEREOF | TAISHO PHARMECUTICAL CO., LTD. (JP) | 2009-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090036448-A1 | PYRIMIDINE DERIVATIVES AND METHODS OF TREATMENT RELATED TO THE USE THEREOF | GPR119, HCRTR2, MCHR1 | NPC1 600/4885RAB9A 3025/4885MAPT 412/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.