Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.69 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | KCNK3 | O14649 | 3/20 | 0.62 |
| ▸ | KCNK9 | Q9NPC2 | 3/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.62 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | PARP1 | P09874 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.56 |
| ▸ | NT5E | P21589 | 1/20 | 0.56 |
| ▸ | GRM5 | P41594 | 1/20 | 0.54 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.54 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24931248 | 0.83 | SMN1; SMN2 (0.89) | HDAC8HDAC6SMN1; SMN2MEN1KMT2A | |
| SCHEMBL30929655 | 0.82 | HDAC6 (1.00) | HDAC8HDAC6SMN1; SMN2MEN1KMT2A | |
| SCHEMBL5242529 | 0.82 | HDAC6 (1.00) | HDAC8HDAC6SMN1; SMN2MEN1KMT2A | |
| SCHEMBL82080 | 0.82 | HDAC8 (0.71) | HDAC8HDAC6SMN1; SMN2MEN1KMT2A | |
| SCHEMBL31540297 | 0.82 | HDAC8 (0.71) | HDAC8HDAC6SMN1; SMN2MEN1KMT2A | |
| SCHEMBL661545 | 0.80 | HDAC8 (0.69) | HDAC8HDAC6SMN1; SMN2MEN1KMT2A | |
| SCHEMBL28744940 | 0.80 | HDAC8 (0.69) | HDAC8HDAC6SMN1; SMN2MEN1KMT2A | |
| SCHEMBL4920155 | 0.80 | HDAC8 (0.69) | HDAC8HDAC6SMN1; SMN2MEN1KMT2A | |
| SCHEMBL9544991 | 0.80 | SMN1; SMN2 (0.76) | HDAC8HDAC6SMN1; SMN2MEN1KMT2A | |
| SCHEMBL315826 | 0.80 | HDAC8 (0.69) | HDAC8HDAC6SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107205972-A | Substituted N- (2- (amino) -2-oxoethyl) benzamide inhibitors of autotaxin and their preparation and use in the treatment of LPA-dependent or LPA-mediated diseases | X-RX股份有限公司 | 2017-09-26 | — | — | CN | disclosed |
| CN-104926810-A | Pyrrolopyridines As Kinase Inhibitors | ARRAY BIOPHARMA INC | 2015-09-23 | — | — | CN | disclosed |
| CN-102089307-B | Pyrrolopyridines as kinase inhibitors | ARRAY BIOPHARMA INC | 2015-07-01 | — | — | CN | disclosed |
| US-20050197350-A1 | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof | TAISHO PHARMACEUTICAL CO., LTD. | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197350-A1 | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof | HCRTR2, MCHR1, MCHR2 | HDAC8 4616/4885HDAC6 2828/4885SMN1; SMN2 1477/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.