Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 5/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 11/20 | 0.34 |
| ▸ | THRA | P10827 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.31 |
| ▸ | CDC7 | O00311 | 1/20 | 0.31 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7705288 | 0.89 | P2RX7 (0.37) | P2RX7ABCB11DHODHTHRBTHRA | |
| SCHEMBL7135587 | 0.88 | P2RX7 (0.38) | P2RX7ABCB11THRBTHRAMEN1 | |
| SCHEMBL6461284 | 0.87 | P2RX7 (0.35) | P2RX7ABCB11THRBTHRAMEN1 | |
| SCHEMBL6462166 | 0.86 | P2RX7 (0.38) | P2RX7ABCB11THRBTHRA | |
| SCHEMBL6462754 | 0.83 | P2RX7 (0.41) | P2RX7ABCB11THRBTHRAMEN1 | |
| SCHEMBL6459898 | 0.83 | THRB (0.39) | P2RX7ABCB11THRBTHRAMEN1 | |
| SCHEMBL6461628 | 0.83 | ADORA2A (0.38) | P2RX7ABCB11THRBTHRA | |
| SCHEMBL6460370 | 0.82 | P2RX7 (0.34) | P2RX7ABCB11THRB | |
| SCHEMBL6460365 | 0.82 | P2RX7 (0.34) | P2RX7ABCB11THRB | |
| SCHEMBL6460658 | 0.80 | THRB (0.35) | P2RX7ABCB11THRBTHRAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6894046-B2 | IL-5 inhibiting 6-azauracil derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-05-17 | — | — | US | disclosed |
| EP-1114046-B1 | INTERLEUKIN-5 INHIBITING 6-AZAURACIL DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2003-04-23 | — | — | EP | disclosed |
| EP-1114046-A1 | INTERLEUKIN-5 INHIBITING 6-AZAURACIL DERIVATIVES | Janssen Pharmaceutica N.V. (BE) | 2001-07-11 | — | — | EP | disclosed |
| WO-2000017195-A1 | INTERLEUKIN-5 INHIBITING 6-AZAURACIL DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2000-03-30 | — | — | WO | disclosed |
| EP-0987265-A1 | Interleukin-5 inhibiting 6-azauracil derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2000-03-22 | — | — | EP | disclosed |