Leucine

Leucine

SCHEMBL6461855

CC(C)C[C@H](N)C(=O)O.CCCC[C@H](NC=O)C(=O)O

nearest known ligand 0.51

Full drug profile on Sugi Atlas →

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
SLC7A5 Q01650 1/20 0.51
SLC1A2 P43004 5/20 0.50
SLC1A1 P43005 4/20 0.50
SLC1A3 P43003 4/20 0.50
GRIK1 P39086 3/20 0.45
GRIK2 Q13002 3/20 0.45
SLC15A1 P46059 1/20 0.45
NOD1 Q9Y239 10/20 0.45
PLA2G2A P14555 2/20 0.40
PLA2G5 P39877 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8628191 0.84 ADH1B (0.46) SLC1A2SLC1A1SLC1A3SLC15A1NOD1
SCHEMBL8628188 0.84 ADH1B (0.46) SLC1A2SLC1A1SLC1A3SLC15A1NOD1
Leucine SCHEMBL379283 0.83 SLC7A5 (0.69) SLC7A5SLC1A2SLC1A1SLC1A3GRIK1
Leucine SCHEMBL379282 0.83 SLC7A5 (0.69) SLC7A5SLC1A2SLC1A1SLC1A3GRIK1
Leucine SCHEMBL1393748 0.82 SLC7A5 (0.50) SLC7A5SLC1A2SLC1A1SLC1A3
Leucine SCHEMBL20471689 0.79 SLC7A5 (0.58) SLC7A5SLC1A2SLC1A1SLC1A3GRIK1
Levacetylleucine SCHEMBL19331538 0.79 ALDH1A1 (0.61) SLC7A5SLC1A2SLC1A1SLC1A3GRIK1
Acetylleucine SCHEMBL20815916 0.79 ALDH1A1 (0.61) SLC7A5SLC1A2SLC1A1SLC1A3GRIK1
SCHEMBL28318789 0.78 ADH1B (0.56) NOD1
SCHEMBL20366018 0.78 ADH1B (0.56) NOD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050042676-A1 Characterising polypeptides ELECTROPHORETICS LIMITED (GB) 2005-02-24 US disclosed