Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.34 |
| ▸ | HRH3 known ✓ | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL6462591 | 1.00 | SIGMAR1 (0.72) | SIGMAR1HRH1HRH3 | |
| SCHEMBL13505898 | 0.92 | SIGMAR1 (0.68) | SIGMAR1HRH1HRH3 | |
| Hydrochloric Acid SCHEMBL5206570 | 0.90 | SIGMAR1 (0.67) | SIGMAR1HRH1HRH3 | |
| T-817 SCHEMBL47997 | 0.84 | SIGMAR1 (1.00) | SIGMAR1HRH1 | |
| T-817 SCHEMBL47995 | 0.84 | SIGMAR1 (1.00) | SIGMAR1HRH1 | |
| T-817 SCHEMBL48064 | 0.84 | SIGMAR1 (1.00) | SIGMAR1HRH1 | |
| T-817 SCHEMBL29371335 | 0.84 | SIGMAR1 (1.00) | SIGMAR1HRH1 | |
| SCHEMBL5206614 | 0.79 | SIGMAR1 (0.47) | SIGMAR1 | |
| T-817 SCHEMBL4134384 | 0.75 | SIGMAR1 (0.86) | SIGMAR1 | |
| T-817 SCHEMBL27725 | 0.74 | SIGMAR1 (1.00) | SIGMAR1HRH1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1514542-A1 | MEDICINAL COMPOSITIONS IMPROVING BRAIN FUNCTION AND METHOD FOR IMPROVING BRAIN FUNCTION | TOYAMA CHEMICAL CO., LTD. (JP) | 2005-03-16 | — | — | EP | disclosed |