SCHEMBL6462900

SCHEMBL6462900

CCS(=O)(=O)N(C(N)=O)c1ccc(Cc2ccc(N(C(N)=O)S(=O)(=O)CC)cc2)cc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRM2 Q14416 1/20 0.40
ALDH1A1 P00352 4/20 0.39
CYP3A4 P08684 1/20 0.39
TSHR P16473 1/20 0.39
MAPK1 P28482 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
HDAC1 Q13547 1/20 0.38
HDAC6 Q9UBN7 1/20 0.38
KMT2A Q03164 2/20 0.37
HPGD P15428 3/20 0.37
SMN1; SMN2 Q16637 3/20 0.37
LMNA P02545 3/20 0.37
HTT P42858 2/20 0.37
PLA2G10 O15496 1/20 0.37
PLA2G2A P14555 1/20 0.37
CNR2 P34972 2/20 0.35
KDM4E B2RXH2 2/20 0.34
STS P08842 1/20 0.34
CA2 P00918 3/20 0.34
CA12 O43570 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9435801 0.89 CNR2 (0.45) GRM2ALDH1A1CYP3A4TSHRMAPK1
SCHEMBL8626825 0.86 ALDH1A1 (0.42) ALDH1A1CYP3A4TSHRMAPK1TDP1
SCHEMBL6464097 0.83 TDP1 (0.40) ALDH1A1CYP3A4TSHRMAPK1TDP1
SCHEMBL6466087 0.83 KMT2A (0.41) ALDH1A1KMT2ALMNAKDM4E
SCHEMBL6464370 0.81 PLA2G10 (0.33) ALDH1A1CYP3A4TSHRMAPK1TDP1
SCHEMBL6463099 0.81 HSP90AA1 (0.49) GRM2ALDH1A1HPGDLMNAPLA2G10
SCHEMBL6469558 0.80 KDM4E (0.40) ALDH1A1KMT2AHPGDLMNAHTT
SCHEMBL6466488 0.79 SAE1 (0.44) ALDH1A1CYP3A4KMT2AHPGDLMNA
SCHEMBL9285401 0.79 CNR2 (0.43) MAPK1HDAC1KMT2ACNR2CA2
SCHEMBL6468780 0.77 PLA2G10 (0.35) ALDH1A1CYP3A4TSHRMAPK1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050255998-A1 Mixture of colour developers CIBA SPECIALTY CHEMICALS CORP. 2005-11-17 US disclosed
US-20050106491-A1 Heat sensitive recording material CIBA SPECIALTY CHEMICALS CORP. 2005-05-19 US disclosed
EP-1480835-A1 HEAT SENSITIVE RECORDING MATERIAL Ciba SC Holding AG (CH) 2004-12-01 EP disclosed
EP-1480836-A1 MIXTURE OF COLOUR DEVELOPERS Ciba SC Holding AG (CH) 2004-12-01 EP disclosed
WO-2003074285-A1 HEAT SENSITIVE RECORDING MATERIAL CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2003-09-12 WO disclosed
WO-2003074284-A1 MIXTURE OF COLOUR DEVELOPERS CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2003-09-12 WO disclosed