SCHEMBL6469558

SCHEMBL6469558

NC(=O)N(c1ccc(Cc2ccc(N(C(N)=O)S(=O)(=O)Cc3ccc(Cl)cc3)cc2)cc1)S(=O)(=O)Cc1ccc(Cl)cc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.40
ALDH1A1 P00352 2/20 0.40
HPGD P15428 1/20 0.40
HSD17B10 Q99714 1/20 0.40
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
MEN1 O00255 1/20 0.38
HTT P42858 1/20 0.38
KMT2A Q03164 1/20 0.38
LMNA P02545 1/20 0.38
CA12 O43570 4/20 0.37
CA1 P00915 4/20 0.37
CA2 P00918 4/20 0.37
CA9 Q16790 4/20 0.37
NPC1 O15118 1/20 0.37
EGFR P00533 2/20 0.37
ERBB2 P04626 2/20 0.37
TP53 P04637 2/20 0.36
MAPT P10636 2/20 0.36
HSP90AA1 P07900 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6463099 0.87 HSP90AA1 (0.49) KDM4EALDH1A1HPGDHSD17B10LMNA
SCHEMBL6466087 0.85 KMT2A (0.41) KDM4EALDH1A1KMT2ALMNATP53
SCHEMBL6466488 0.82 SAE1 (0.44) ALDH1A1HPGDCYP2C9CYP2C19MEN1
SCHEMBL6462900 0.80 GRM2 (0.40) KDM4EALDH1A1HPGDHTTKMT2A
SCHEMBL27521558 0.76 HSP90AA1 (0.59) KDM4EALDH1A1HPGDHSD17B10CA1
SCHEMBL8626825 0.76 ALDH1A1 (0.42) KDM4EALDH1A1HPGDHTTKMT2A
SCHEMBL6464370 0.75 PLA2G10 (0.33) ALDH1A1KMT2ACA12CA1CA2
SCHEMBL6537387 0.74 MEN1 (0.44) KDM4EALDH1A1HPGDHSD17B10MEN1
SCHEMBL6468780 0.74 PLA2G10 (0.35) ALDH1A1KMT2ACA12CA1CA2
SCHEMBL9435801 0.73 CNR2 (0.45) ALDH1A1HPGDHSD17B10LMNACA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050255998-A1 Mixture of colour developers CIBA SPECIALTY CHEMICALS CORP. 2005-11-17 US disclosed
EP-1480835-A1 HEAT SENSITIVE RECORDING MATERIAL Ciba SC Holding AG (CH) 2004-12-01 EP disclosed
EP-1480836-A1 MIXTURE OF COLOUR DEVELOPERS Ciba SC Holding AG (CH) 2004-12-01 EP disclosed
WO-2003074285-A1 HEAT SENSITIVE RECORDING MATERIAL CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2003-09-12 WO disclosed
WO-2003074284-A1 MIXTURE OF COLOUR DEVELOPERS CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2003-09-12 WO disclosed
US-5612280-A AROMATIC SULFONYLUREA AND SULFONYLTHIOUREA DERIVATIVES AS COLOR DEVELOPERS; COLORFASTNESS, STORAGE STABILITY, WHITENESS NEW OJI PAPER CO., LTD. (JP) 1997-03-18 US disclosed