Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 17/20 | 0.39 |
| ▸ | KDR | P35968 | 13/20 | 0.39 |
| ▸ | EGFR | P00533 | 4/20 | 0.38 |
| ▸ | LCK | P06239 | 2/20 | 0.37 |
| ▸ | YES1 | P07947 | 2/20 | 0.37 |
| ▸ | CSK | P41240 | 2/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.35 |
| ▸ | GAK | O14976 | 1/20 | 0.35 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.35 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.35 |
| ▸ | STK10 | O94804 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | LYN | P07948 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6970862 | 0.84 | SRC (0.47) | SRCKDREGFRLCKYES1 | |
| SCHEMBL6387383 | 0.81 | SRC (0.45) | SRCKDREGFRLCKYES1 | |
| SCHEMBL4594558 | 0.78 | SRC (0.55) | SRCKDREGFRLCKYES1 | |
| SCHEMBL6966011 | 0.75 | SRC (0.41) | SRCKDREGFRLCKYES1 | |
| SCHEMBL5735755 | 0.74 | SRC (0.59) | SRCKDREGFRLCKYES1 | |
| SCHEMBL7689206 | 0.73 | EGFR (0.47) | EGFRCHRNB2CHRNA4AURKB | |
| SCHEMBL13638737 | 0.72 | EGFR (0.42) | EGFR | |
| SCHEMBL7097966 | 0.71 | CHRNA3 (0.49) | CHRNB2CHRNA4 | |
| SCHEMBL5747605 | 0.69 | EGFR (0.39) | SRCEGFRLCKKITACVR1B | |
| SCHEMBL6978768 | 0.69 | SRC (0.44) | SRCKDREGFRLCKYES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562612-A1 | COMBINATION PRODUCT OF INHIBITOR OF THE SRC FAMILY OF NON-RECEPTOR TYROSINE KINASES AND GEMCITABINE | Astrazeneca AB (SE) | 2005-08-17 | — | — | EP | disclosed |
| WO-2004043472-A1 | COMBINATION PRODUCT OF INHIBITOR OF THE SRC FAMILY OF NON-RECEPTOR TYROSINE KINASES AND GEMCITABINE | ASTRAZENECA AB (SE) | 2004-05-27 | — | — | WO | disclosed |