Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA3 | P32297 | 5/20 | 0.49 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.49 |
| ▸ | CHRNB2 | P17787 | 6/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 6/20 | 0.44 |
| ▸ | AKT1 | P31749 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.41 |
| ▸ | CHRNG | P07510 | 1/20 | 0.41 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.41 |
| ▸ | CHRND | Q07001 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7103614 | 0.95 | HRH3 (0.48) | CHRNA3CHRNB4CHRNB2CHRNA4HRH3 | |
| SCHEMBL7103794 | 0.89 | CHRNA3 (0.46) | CHRNA3CHRNB4CHRNB2CHRNA4CHRNA1 | |
| SCHEMBL8436385 | 0.82 | CHRNB2 (0.59) | CHRNA3CHRNB4CHRNB2CHRNA4CHRNA1 | |
| Hydrochloric Acid SCHEMBL7410981 | 0.81 | CHRNB2 (0.58) | CHRNA3CHRNB4CHRNB2CHRNA4CHRNA1 | |
| SCHEMBL7689206 | 0.79 | EGFR (0.47) | CHRNA3CHRNB4CHRNB2CHRNA4 | |
| SCHEMBL6608164 | 0.79 | CHRNB2 (0.58) | CHRNA3CHRNB4CHRNB2CHRNA4CHRNA1 | |
| SCHEMBL6610063 | 0.78 | LTA4H (0.57) | — | |
| SCHEMBL8440937 | 0.77 | CHRNA3 (0.75) | CHRNA3CHRNB4CHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL7409148 | 0.76 | CHRNA3 (0.73) | CHRNA3CHRNB4CHRNB2CHRNA4 | |
| SCHEMBL2482746 | 0.75 | NFE2L2 (0.58) | CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2003500393-A | — | — | 2003-01-07 | — | — | JP | claimed |
| EP-1185513-A2 | ARYL SUBSTITUTED ALKYLAMINES CAPABLE OF ACTIVATING NICOTINIC CHOLINERGIC RECEPTORS | Targacept, Inc. (US) | 2002-03-13 | — | — | EP | claimed |
| WO-2000071520-A2 | ARYL SUBSTITUTED ALKYLAMINES CAPABLE OF ACTIVATING NICOTINIC CHOLINERGIC RECEPTORS | TARGACEPT, INC. (US) | 2000-11-30 | — | — | WO | claimed |