Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.56 |
| ▸ | SRC | P12931 | 2/20 | 0.55 |
| ▸ | KDR | P35968 | 1/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | SCN1A | P35498 | 1/20 | 0.53 |
| ▸ | HTR2B | P41595 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.53 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | MET | P08581 | 1/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14495853 | 0.94 | KDM4E (0.64) | GRM4ALDH1A1KDM4ESIGMAR1SRC | |
| SCHEMBL30499279 | 0.94 | KDM4E (0.64) | GRM4ALDH1A1KDM4ESIGMAR1SRC | |
| SCHEMBL27006796 | 0.87 | HRH3 (0.54) | ALDH1A1KDM4ESIGMAR1HRH3CHRM1 | |
| SCHEMBL4506955 | 0.83 | SRC (0.59) | GRM4ALDH1A1KDM4ESIGMAR1SRC | |
| Hydrochloric Acid SCHEMBL7865977 | 0.82 | SRC (0.58) | GRM4ALDH1A1KDM4ESIGMAR1SRC | |
| SCHEMBL18256940 | 0.82 | SIGMAR1 (0.50) | GRM4ALDH1A1KDM4ESIGMAR1SRC | |
| SCHEMBL2700790 | 0.82 | HRH3 (0.49) | GRM4ALDH1A1KDM4ESIGMAR1SRC | |
| SCHEMBL25131312 | 0.81 | KDM4E (0.56) | GRM4ALDH1A1KDM4ESIGMAR1HRH3 | |
| SCHEMBL30499299 | 0.81 | KDM4E (0.56) | GRM4ALDH1A1KDM4ESIGMAR1HRH3 | |
| SCHEMBL15260249 | 0.80 | ALDH1A1 (0.57) | ALDH1A1KDM4ESIGMAR1HRH3MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6977259-B2 | Quinoline derivatives and their use as aurora 2 kinase inhibitors | ASTRAZENECA AB (SE) | 2005-12-20 | — | — | US | disclosed |
| US-20030105129-A1 | Chemical compounds | ASTRAZENECA AB (SE) | 2003-06-05 | — | — | US | disclosed |
| EP-1294709-A2 | QUINOLINE DERIVATIVES AND THEIR USE AS AURORA 2 KINASE INHIBITORS | AstraZeneca AB (SE) | 2003-03-26 | — | — | EP | disclosed |
| WO-2001055116-A2 | QUINOLINE DERIVATIVES AND THEIR USE AS AURORA 2 KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2001-08-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030105129-A1 | Chemical compounds | AURKC, AURKA, AURKB | GRM4 4395/4885ALDH1A1 2111/4885KDM4E 1381/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.