SCHEMBL6464974

SCHEMBL6464974

Cc1cc(C)c(C(=O)OOC(=O)c2c(C)cc(C)cc2[Si](C)(C)C)c([Si](C)(C)C)c1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.39
L3MBTL1 Q9Y468 2/20 0.36
CYP2C9 P11712 1/20 0.36
CYP2C19 P33261 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
TAS1R3 Q7RTX0 3/20 0.34
TAS1R1 Q7RTX1 3/20 0.34
TAS1R2 Q8TE23 3/20 0.34
MAPT P10636 2/20 0.34
MAPK1 P28482 1/20 0.34
LMNA P02545 2/20 0.34
ELANE P08246 1/20 0.34
SMN1; SMN2 Q16637 2/20 0.33
CYP3A4 P08684 1/20 0.33
ACHE P22303 1/20 0.33
KMT2A Q03164 2/20 0.33
GAA P10253 1/20 0.33
KDM4E B2RXH2 1/20 0.33
MEN1 O00255 1/20 0.33
HPGD P15428 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL125935 0.82 CYP3A4 (0.41) ALDH1A1L3MBTL1NPSR1TAS1R3TAS1R1
SCHEMBL6464548 0.75 CYP3A4 (0.36) ALDH1A1MAPK1SMN1; SMN2CYP3A4ACHE
SCHEMBL7628109 0.75 CYP3A4 (0.36) ALDH1A1L3MBTL1NPSR1TAS1R3TAS1R1
SCHEMBL7634222 0.73 KDM4E (0.37) ALDH1A1L3MBTL1NPSR1TAS1R3TAS1R1
SCHEMBL7217103 0.73 HPGD (0.56) ALDH1A1L3MBTL1NPSR1MAPTMAPK1
SCHEMBL11649994 0.72 POLB (0.43) L3MBTL1LMNASMN1; SMN2KMT2AGAA
SCHEMBL7629784 0.71 ALDH1A1 (0.38) ALDH1A1L3MBTL1CYP2C9CYP2C19NPSR1
SCHEMBL18203129 0.69 LMNA (0.61) ALDH1A1NPSR1MAPTLMNAKMT2A
SCHEMBL7627869 0.69 TSHR (0.39) ALDH1A1L3MBTL1CYP2C19MAPTMAPK1
SCHEMBL7630320 0.69 L3MBTL1 (0.36) ALDH1A1L3MBTL1TAS1R3TAS1R1TAS1R2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6951904-B1 Process for increasing the melt strength of polypropylene POLYMERS AUSTRALIA PTY LIMITED (AU) 2005-10-04 US claimed
EP-1080148-A4 PROCESS FOR INCREASING THE MELT STRENGTH OF POLYPROPYLENE POLYMERS AUSTRALIA PTY LTD (AU) 2003-02-05 EP claimed
EP-1080148-A1 PROCESS FOR INCREASING THE MELT STRENGTH OF POLYPROPYLENE Polymers Australia PTY Limited (AU) 2001-03-07 EP claimed
WO-1999036466-A1 PROCESS FOR INCREASING THE MELT STRENGTH OF POLYPROPYLENE POLYMERS AUSTRALIA PTY LIMITED (AU) 1999-07-22 WO claimed
US-6951904-B1 Process for increasing the melt strength of polypropylene POLYMERS AUSTRALIA PTY LIMITED (AU) 2005-10-04 US disclosed
EP-1080148-A4 PROCESS FOR INCREASING THE MELT STRENGTH OF POLYPROPYLENE POLYMERS AUSTRALIA PTY LTD (AU) 2003-02-05 EP disclosed
EP-1080148-A1 PROCESS FOR INCREASING THE MELT STRENGTH OF POLYPROPYLENE Polymers Australia PTY Limited (AU) 2001-03-07 EP disclosed
WO-1999036466-A1 PROCESS FOR INCREASING THE MELT STRENGTH OF POLYPROPYLENE POLYMERS AUSTRALIA PTY LIMITED (AU) 1999-07-22 WO disclosed