Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 3/20 | 0.47 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.43 |
| ▸ | ABL1 | P00519 | 2/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.41 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6462293 | 0.78 | ADORA1 (0.65) | ADORA2AADORA1CLK4GSK3BDYRK1A | |
| SCHEMBL7022182 | 0.76 | MAPK8 (0.47) | MAPK8MAPK9ADORA1CLK4GAA | |
| SCHEMBL7019672 | 0.74 | MAPK8 (0.48) | MAPK8MAPK9ADORA2AADORA1GAA | |
| SCHEMBL7015455 | 0.74 | ALDH1A1 (0.46) | MAPK8MAPK9ADORA2AADORA1CLK4 | |
| SCHEMBL6468541 | 0.69 | MAPK14 (0.53) | ADORA2AADORA1CLK4GSK3BDYRK1A | |
| SCHEMBL4755334 | 0.68 | MAPK14 (0.48) | ADORA2AADORA1GAAMAPTKDM4E | |
| SCHEMBL13514256 | 0.68 | KMT2A (0.53) | MAPK8MAPK9GAAMAPTKDM4E | |
| SCHEMBL7020462 | 0.67 | SQOR (0.48) | ADORA2AADORA1GAAMAPTKDM4E | |
| SCHEMBL7014230 | 0.67 | ALDH1A1 (0.61) | MAPK8MAPK9ADORA2AADORA1CLK4 | |
| SCHEMBL7020305 | 0.66 | ALDH1A1 (0.60) | MAPK8MAPK9ADORA2AADORA1CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050182105-A1 | Method of using 3-cyano-4-arylpyridine derivatives as modulators of androgen receptor function | BRISTOL-MYERS SQUIBB COMPANY | 2005-08-18 | — | — | US | claimed |
| US-20050182105-A1 | Method of using 3-cyano-4-arylpyridine derivatives as modulators of androgen receptor function | BRISTOL-MYERS SQUIBB COMPANY | 2005-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050182105-A1 | Method of using 3-cyano-4-arylpyridine derivatives as modulators of androgen receptor function | NR3C2, NR4A3, NR3C1 | MAPK8 2977/4885MAPK9 3689/4885ADORA2A 754/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.