SCHEMBL6465065

SCHEMBL6465065

COc1ccc(S(=O)(=O)N(C(N)=O)c2cccc(N(C(N)=O)S(=O)(=O)c3ccc(OC)cc3)c2)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TP53 P04637 5/20 0.54
LMNA P02545 3/20 0.51
ALDH1A1 P00352 4/20 0.50
POLB P06746 1/20 0.50
MAPT P10636 5/20 0.49
THRB P10828 1/20 0.49
USP2 O75604 1/20 0.49
HPGD P15428 2/20 0.48
PKM P14618 1/20 0.48
ALOX15 P16050 1/20 0.48
ALOX12 P18054 1/20 0.48
HTT P42858 1/20 0.48
HSD17B10 Q99714 1/20 0.48
TDP1 Q9NUW8 1/20 0.48
CYP1A2 P05177 1/20 0.48
CYP3A4 P08684 1/20 0.48
GAA P10253 1/20 0.48
CYP2C9 P11712 1/20 0.48
CYP2C19 P33261 1/20 0.48
KEAP1 Q14145 3/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6241748 0.84 LMNA (0.55) TP53LMNAALDH1A1POLBMAPT
SCHEMBL9478142 0.83 TP53 (0.73) TP53LMNAALDH1A1POLBMAPT
SCHEMBL8620628 0.81 TP53 (0.55) TP53LMNAALDH1A1POLBMAPT
SCHEMBL6324948 0.78 LMNA (0.63) TP53LMNAALDH1A1POLBMAPT
SCHEMBL6243492 0.78 TP53 (0.53) TP53LMNAALDH1A1POLBMAPT
SCHEMBL1347016 0.77 PPARG (0.48) TP53LMNAALDH1A1POLBMAPT
SCHEMBL29445563 0.77 PPARG (0.48) TP53LMNAALDH1A1POLBMAPT
SCHEMBL6240949 0.76 LMNA (0.50) TP53LMNAALDH1A1POLBMAPT
SCHEMBL21753689 0.75 LMNA (0.49) TP53LMNAALDH1A1POLBMAPT
SCHEMBL6326721 0.75 TP53 (0.53) TP53LMNAMAPTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050255998-A1 Mixture of colour developers CIBA SPECIALTY CHEMICALS CORP. 2005-11-17 US disclosed
US-20050106491-A1 Heat sensitive recording material CIBA SPECIALTY CHEMICALS CORP. 2005-05-19 US disclosed
EP-1480836-A1 MIXTURE OF COLOUR DEVELOPERS Ciba SC Holding AG (CH) 2004-12-01 EP disclosed
WO-2003074284-A1 MIXTURE OF COLOUR DEVELOPERS CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2003-09-12 WO disclosed
US-5612280-A AROMATIC SULFONYLUREA AND SULFONYLTHIOUREA DERIVATIVES AS COLOR DEVELOPERS; COLORFASTNESS, STORAGE STABILITY, WHITENESS NEW OJI PAPER CO., LTD. (JP) 1997-03-18 US disclosed