Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.36 |
| ▸ | FYN | P06241 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.32 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.31 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.31 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | CDK9 | P50750 | 1/20 | 0.31 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6429820 | 0.79 | KDM4E (0.34) | HPGDCYP3A4CRHR1KDM4EALDH1A1 | |
| SCHEMBL5844146 | 0.74 | CRHR1 (0.51) | HPGDCYP3A4CRHR1 | |
| SCHEMBL6445649 | 0.74 | HPGDS (0.38) | HPGDCYP3A4NPC1RAB9A | |
| SCHEMBL6798443 | 0.68 | CRHR1 (0.57) | HPGDCYP3A4CRHR1 | |
| SCHEMBL6803031 | 0.68 | CRHR1 (0.46) | HPGDCYP3A4CRHR1 | |
| SCHEMBL5844798 | 0.67 | CRHR1 (0.49) | CRHR1 | |
| SCHEMBL5843991 | 0.65 | CRHR1 (0.69) | CRHR1 | |
| SCHEMBL5843230 | 0.65 | CRHR1 (0.61) | CRHR1 | |
| SCHEMBL5843235 | 0.65 | CRHR1 (0.61) | CRHR1 | |
| SCHEMBL6804838 | 0.65 | CRHR1 (0.49) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6844351-B1 | Corticotropin releasing factor antagonists | PFIZER INC. (US) | 2005-01-18 | — | — | US | disclosed |