Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 6/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 6/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | CTSB | P07858 | 6/20 | 0.31 |
| ▸ | CTSS | P25774 | 4/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6138265 | 0.92 | CTSL (0.30) | CTSL | |
| SCHEMBL16486253 | 0.80 | JAK2 (0.31) | JAK2JAK1 | |
| SCHEMBL16486198 | 0.79 | KMT2A (0.35) | LMNABLM | |
| SCHEMBL7157738 | 0.76 | CYP2C19 (0.33) | CYP2C19USP2ALDH1A1LMNACYP1A2 | |
| SCHEMBL5019821 | 0.75 | CYP2C19 (0.48) | CYP2C19USP2ALDH1A1LMNACYP1A2 | |
| SCHEMBL3370066 | 0.74 | CTSL (0.41) | CTSLCTSKDPP4CTSBCTSS | |
| SCHEMBL9104945 | 0.74 | MME (0.45) | DPP4CYP2C19ALDH1A1 | |
| SCHEMBL22765979 | 0.73 | P2RX7 (0.41) | CTSLCTSKDPP4CTSBCTSS | |
| SCHEMBL23573562 | 0.72 | MME (0.37) | CYP2C19ALDH1A1LMNA | |
| SCHEMBL14165607 | 0.72 | ALDH1A1 (0.42) | CYP2C19USP2ALDH1A1LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603915-A1 | SUBSTITUTED 8 -PYRIDINYL-DIHYDROSPIRO- CYCLOALKYL -PYRIMIDO 1,2-a PYRIMIDIN-6-ONE AND 8 -PYRIMIDIN YL-DIHYDROSPIRO- CYCLOALKYL -PYRIMIDO 1,2-a PYRIMIDIN-6-ONE DERIVATIVES AND THEIR USE AGAINST NEUROGENERATIVE DISEASES | Sanofi-Aventis (FR) | 2005-12-14 | — | — | EP | disclosed |
| WO-2004078760-A1 | SUBSTITUTED 8'-PYRIDINYL-DIHYDROSPIRO-[CYCLOALKYL]-PYRIMIDO [1,2-a] PYRIMIDIN-6-ONE AND 8'-PYRIMIDINYL-DIHYDROSPIRO-[CYCLOALKYL]-PYRIMIDO [1,2-a] PYRIMIDIN-6-ONE DERIVATIVES AND THEIR USE AGAINST NEUROGENERATIVE DISEASES | SANOFI-AVENTIS (FR) | 2004-09-16 | — | — | WO | disclosed |