Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.50 |
| ▸ | ITK | Q08881 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 9/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6468751 | 0.89 | ITK (0.44) | KIF11ITKPARP1IRAK4NPC1 | |
| SCHEMBL6500119 | 0.86 | ITK (0.43) | KIF11ITKPARP1IRAK4NPC1 | |
| SCHEMBL6500141 | 0.85 | ITK (0.44) | ITKPARP1IRAK4NPC1RAB9A | |
| SCHEMBL6467341 | 0.85 | ITK (0.40) | KIF11ITKPARP1IRAK4NPC1 | |
| SCHEMBL6502246 | 0.83 | ITK (0.44) | ITKPARP1IRAK4NPC1 | |
| SCHEMBL6470190 | 0.82 | PARP1 (0.38) | KIF11PARP1NPC1RAB9ASCN9A | |
| SCHEMBL6469788 | 0.82 | KMT2A (0.46) | ITKIRAK4NPC1RAB9AF10 | |
| SCHEMBL6467527 | 0.82 | KDM4E (0.47) | ITKPARP1IRAK4NPC1RAB9A | |
| SCHEMBL6506078 | 0.81 | ITK (0.39) | KIF11ITKPARP1IRAK4NPC1 | |
| SCHEMBL6497900 | 0.81 | ITK (0.41) | ITKPARP1IRAK4NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050197338-A1 | Substituted pyrazole urea compounds for the treatment of inflammation | PHARMACIA AND UPJOHN COMPANY LLC | 2005-09-08 | — | — | US | disclosed |
| WO-2005037797-A1 | SUBSTITUTED PYRAZOLE UREA COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA CORPORATION (US) | 2005-04-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197338-A1 | Substituted pyrazole urea compounds for the treatment of inflammation | IL4, ARG2, CASP4 | KIF11 4732/4885ITK 4236/4885PARP1 1904/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.