Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 6/20 | 0.45 |
| ▸ | IKBKB | O14920 | 1/20 | 0.42 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | ITK | Q08881 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 9/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6470182 | 0.87 | SCN9A (0.43) | SCN9AIKBKBITKMAPK10PARP1 | |
| SCHEMBL6528133 | 0.86 | SCN9A (0.56) | SCN9ASCN10ACYP2C9ITKCYP3A4 | |
| SCHEMBL6469636 | 0.85 | SCN9A (0.41) | SCN9ASCN10ACYP2C9ITKPARP1 | |
| SCHEMBL6468674 | 0.85 | ITK (0.43) | SCN9AIKBKBITKMAPK10NPC1 | |
| SCHEMBL6468728 | 0.85 | IKBKB (0.42) | SCN9AIKBKBITKMAPK10NPC1 | |
| SCHEMBL6508710 | 0.83 | IKBKB (0.47) | SCN9AIKBKBITKMAPK10PARP1 | |
| SCHEMBL6500908 | 0.83 | SCN9A (0.42) | SCN9ASCN10ACYP2C9ITKPARP1 | |
| SCHEMBL6498765 | 0.82 | MAPT (0.46) | SCN9AIKBKBCYP2C9ITKNPC1 | |
| SCHEMBL6467585 | 0.81 | SCN9A (0.44) | SCN9AIKBKBITKMAPK10NPC1 | |
| SCHEMBL6505234 | 0.81 | ITK (0.49) | SCN9AIKBKBITKPARP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050197338-A1 | Substituted pyrazole urea compounds for the treatment of inflammation | PHARMACIA AND UPJOHN COMPANY LLC | 2005-09-08 | — | — | US | disclosed |
| WO-2005037797-A1 | SUBSTITUTED PYRAZOLE UREA COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA CORPORATION (US) | 2005-04-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197338-A1 | Substituted pyrazole urea compounds for the treatment of inflammation | IL4, ARG2, CASP4 | SCN9A 4159/4885IKBKB 664/4885SCN10A 3527/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.