Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | UCHL1 | P09936 | 3/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6468031 | 0.89 | ALDH1A1 (0.45) | GPR119ALDH1A1HSD11B1TSHRMEN1 | |
| SCHEMBL6466237 | 0.89 | ALDH1A1 (0.47) | GPR119ALDH1A1HSD11B1TSHRMEN1 | |
| SCHEMBL6467149 | 0.88 | ALDH1A1 (0.44) | GPR119ALDH1A1HSD11B1TSHRMEN1 | |
| SCHEMBL6468162 | 0.88 | ALDH1A1 (0.44) | GPR119ALDH1A1HSD11B1TSHRMEN1 | |
| SCHEMBL2725756 | 0.86 | CPT1A (0.43) | HSD11B1TRPV1BAZ2A | |
| SCHEMBL1276058 | 0.81 | NR1H2 (0.44) | ALDH1A1HSD11B1TSHRMEN1KMT2A | |
| SCHEMBL6468249 | 0.81 | HSD11B1 (0.45) | ALDH1A1HSD11B1TSHRMEN1KMT2A | |
| SCHEMBL1276060 | 0.81 | NR1H2 (0.44) | ALDH1A1HSD11B1TSHRMEN1KMT2A | |
| SCHEMBL24926366 | 0.80 | ALDH1A1 (0.43) | ALDH1A1HSD11B1TSHRMEN1KMT2A | |
| SCHEMBL3512446 | 0.79 | RAB9A (0.43) | ALDH1A1HSD11B1TSHRL3MBTL1UCHL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012054510-A1 | OXADIAZOLE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF | COMENTIS, INC. (US) | 2012-04-26 | — | — | WO | disclosed |