SCHEMBL6467115

SCHEMBL6467115

C[Si](C)(C)c1cccc(C(=O)OOC(=O)c2cccc([Si](C)(C)C)c2[Si](C)(C)C)c1[Si](C)(C)C

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.34
TSHR P16473 5/20 0.33
LMNA P02545 2/20 0.33
F2 P00734 1/20 0.33
ALDH1A1 P00352 4/20 0.32
CFTR P13569 1/20 0.32
HSD17B10 Q99714 1/20 0.32
KDM4E B2RXH2 2/20 0.31
POLB P06746 1/20 0.31
ATM Q13315 1/20 0.31
TRPA1 O75762 2/20 0.31
CA12 O43570 1/20 0.31
CA1 P00915 1/20 0.31
CA2 P00918 1/20 0.31
CA7 P43166 1/20 0.31
CA9 Q16790 1/20 0.31
CA14 Q9ULX7 1/20 0.31
GLA P06280 1/20 0.30
IDO1 P14902 1/20 0.30
TDP1 Q9NUW8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9716919 0.82 LMNA (0.41) CYP1A2TSHRLMNAF2ALDH1A1
SCHEMBL11538179 0.79 PARP1 (0.42) TSHRALDH1A1HSD17B10KDM4E
SCHEMBL20510176 0.75 AKR1C3 (0.48) ALDH1A1POLBATMTDP1L3MBTL1
SCHEMBL8832411 0.73 IDO1 (0.32) IDO1
SCHEMBL3110894 0.72 IDO1 (0.41) IDO1
SCHEMBL4077241 0.70 IDO1 (0.30) IDO1
SCHEMBL2813885 0.67 IDO1 (0.35) IDO1
SCHEMBL34472984 0.67 ALDH1A1 (0.52) TSHRALDH1A1HSD17B10KDM4ECA12
SCHEMBL20510174 0.67 ALDH1A1 (0.45) CYP1A2TSHRLMNAALDH1A1KDM4E
SCHEMBL9860862 0.67 ALDH1A1 (0.38) CYP1A2TSHRLMNAALDH1A1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6951904-B1 Process for increasing the melt strength of polypropylene POLYMERS AUSTRALIA PTY LIMITED (AU) 2005-10-04 US claimed
EP-1080148-A4 PROCESS FOR INCREASING THE MELT STRENGTH OF POLYPROPYLENE POLYMERS AUSTRALIA PTY LTD (AU) 2003-02-05 EP claimed
EP-1080148-A1 PROCESS FOR INCREASING THE MELT STRENGTH OF POLYPROPYLENE Polymers Australia PTY Limited (AU) 2001-03-07 EP claimed
WO-1999036466-A1 PROCESS FOR INCREASING THE MELT STRENGTH OF POLYPROPYLENE POLYMERS AUSTRALIA PTY LIMITED (AU) 1999-07-22 WO claimed
US-6951904-B1 Process for increasing the melt strength of polypropylene POLYMERS AUSTRALIA PTY LIMITED (AU) 2005-10-04 US disclosed
EP-1080148-A4 PROCESS FOR INCREASING THE MELT STRENGTH OF POLYPROPYLENE POLYMERS AUSTRALIA PTY LTD (AU) 2003-02-05 EP disclosed
EP-1080148-A1 PROCESS FOR INCREASING THE MELT STRENGTH OF POLYPROPYLENE Polymers Australia PTY Limited (AU) 2001-03-07 EP disclosed
WO-1999036466-A1 PROCESS FOR INCREASING THE MELT STRENGTH OF POLYPROPYLENE POLYMERS AUSTRALIA PTY LIMITED (AU) 1999-07-22 WO disclosed