Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TRPC3 | Q13507 | 2/20 | 0.37 |
| ▸ | TRPC6 | Q9Y210 | 2/20 | 0.37 |
| ▸ | NAA50 | Q9GZZ1 | 2/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10289968 | 0.92 | TRPV1 (0.39) | TRPV1POLBBAZ2ATSHRSMN1; SMN2 | |
| SCHEMBL27901455 | 0.89 | TRPV1 (0.41) | TRPV1POLBBAZ2ATSHRSMN1; SMN2 | |
| SCHEMBL166998 | 0.87 | TRPV1 (0.43) | TRPV1POLBBAZ2ATSHRSMN1; SMN2 | |
| SCHEMBL166997 | 0.87 | TRPV1 (0.43) | TRPV1POLBBAZ2ATSHRSMN1; SMN2 | |
| SCHEMBL166241 | 0.87 | TRPV1 (0.42) | TRPV1POLBBAZ2ATSHRSMN1; SMN2 | |
| SCHEMBL166240 | 0.87 | TRPV1 (0.42) | TRPV1POLBBAZ2ATSHRSMN1; SMN2 | |
| SCHEMBL6466071 | 0.85 | POLB (0.38) | TRPV1POLBBAZ2ATSHRSMN1; SMN2 | |
| SCHEMBL2710768 | 0.85 | GRM5 (0.44) | TRPV1 | |
| SCHEMBL10291020 | 0.85 | GRM5 (0.44) | TRPV1 | |
| SCHEMBL2726428 | 0.84 | NAA50 (0.39) | TRPV1POLBBAZ2ATSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012054510-A1 | OXADIAZOLE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF | COMENTIS, INC. (US) | 2012-04-26 | — | — | WO | disclosed |