SCHEMBL6467693

SCHEMBL6467693

O=C(Nc1ccc(Cc2ccc(NC(=O)NS(=O)(=O)c3ccc(Cc4ccccc4)cc3)cc2)cc1)NS(=O)(=O)c1ccc(Cc2ccccc2)cc1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.64
CYP2C9 P11712 1/20 0.59
CA2 P00918 6/20 0.57
CA1 P00915 5/20 0.57
CA9 Q16790 5/20 0.57
CA12 O43570 4/20 0.57
L3MBTL1 Q9Y468 1/20 0.54
TP53 P04637 1/20 0.54
CA4 P22748 1/20 0.54
CA6 P23280 1/20 0.54
CA5A P35218 1/20 0.54
CA7 P43166 1/20 0.54
CA13 Q8N1Q1 1/20 0.54
CA14 Q9ULX7 1/20 0.54
MMP1 P03956 1/20 0.53
MMP2 P08253 1/20 0.53
MMP9 P14780 1/20 0.53
MMP8 P22894 1/20 0.53
MMP13 P45452 1/20 0.53
PPARG P37231 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7774821 0.95 LMNA (0.61) LMNACYP2C9CA2CA1CA9
SCHEMBL6469820 0.93 LMNA (0.59) LMNACYP2C9CA2CA1CA9
SCHEMBL8662451 0.90 LMNA (0.57) LMNACYP2C9CA2CA1CA9
SCHEMBL6462887 0.89 CA1 (0.60) LMNACYP2C9CA2CA1CA9
SCHEMBL8661000 0.89 CA12 (0.60) CA2CA1CA9CA12MMP1
SCHEMBL27680 0.87 CA12 (0.72) LMNACA2CA1CA9CA12
SCHEMBL8418171 0.87 ALDH1A1 (0.57) LMNACA2CA1CA9CA12
SCHEMBL8417032 0.87 EGFR (0.57) LMNACA2CA1CA9CA12
SCHEMBL6297294 0.85 LMNA (0.79) LMNACYP2C9CA2CA1CA9
SCHEMBL8418076 0.85 CA2 (0.58) LMNACYP2C9CA2CA1CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050255998-A1 Mixture of colour developers CIBA SPECIALTY CHEMICALS CORP. 2005-11-17 US disclosed
US-20050106491-A1 Heat sensitive recording material CIBA SPECIALTY CHEMICALS CORP. 2005-05-19 US disclosed
EP-1480835-A1 HEAT SENSITIVE RECORDING MATERIAL Ciba SC Holding AG (CH) 2004-12-01 EP disclosed
EP-1480836-A1 MIXTURE OF COLOUR DEVELOPERS Ciba SC Holding AG (CH) 2004-12-01 EP disclosed
WO-2003074284-A1 MIXTURE OF COLOUR DEVELOPERS CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2003-09-12 WO disclosed
WO-2003074285-A1 HEAT SENSITIVE RECORDING MATERIAL CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2003-09-12 WO disclosed
EP-0792755-B1 Thermosensitive recording material OJI PAPER CO (JP) 1998-11-11 EP disclosed
EP-0792755-A1 Thermosensitive recording material OJI PAPER COMPANY LIMITED (JP) 1997-09-03 EP disclosed
US-5612280-A AROMATIC SULFONYLUREA AND SULFONYLTHIOUREA DERIVATIVES AS COLOR DEVELOPERS; COLORFASTNESS, STORAGE STABILITY, WHITENESS NEW OJI PAPER CO., LTD. (JP) 1997-03-18 US disclosed
EP-0604832-A2 Thermosensitive recording material NEW OJI PAPER CO., LTD. (JP) 1994-07-06 EP disclosed