Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
| ▸ | HTR7 | P34969 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29671577 | 1.00 | KMT2A (0.59) | KMT2AMEN1GAASMN1; SMN2ATM | |
| SCHEMBL4334443 | 0.84 | ALDH1A1 (0.55) | KMT2AMEN1GAASMN1; SMN2ATM | |
| SCHEMBL5362724 | 0.84 | KMT2A (0.53) | KMT2AMEN1GAASMN1; SMN2ATM | |
| SCHEMBL1496589 | 0.84 | KMT2A (0.60) | KMT2AMEN1GAASMN1; SMN2ATM | |
| SCHEMBL16180345 | 0.84 | KMT2A (0.53) | KMT2AMEN1GAASMN1; SMN2ATM | |
| SCHEMBL263217 | 0.84 | KMT2A (0.53) | KMT2AMEN1GAASMN1; SMN2ATM | |
| SCHEMBL11565366 | 0.84 | KMT2A (0.53) | KMT2AMEN1GAASMN1; SMN2ATM | |
| SCHEMBL5362727 | 0.84 | KMT2A (0.53) | KMT2AMEN1GAASMN1; SMN2ATM | |
| SCHEMBL27514088 | 0.82 | KMT2A (0.51) | KMT2AMEN1GAASMN1; SMN2ATM | |
| SCHEMBL5371216 | 0.81 | HTR7 (0.54) | KMT2AMEN1GAASMN1; SMN2ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106008375-A | Preparation method of novel liquid crystal display enhancing luminescence agent | 昆山海卓生物医药有限公司 | 2016-10-12 | — | — | CN | disclosed |
| WO-2013029338-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2013-03-07 | — | — | WO | disclosed |
| CN-102079731-A | Method for synthesizing 2-(3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazole formic acid | SHANGHAI HECHEN MEDICAL ENGINEERING CO LTD | 2011-06-01 | — | — | CN | disclosed |
| US-20050038019-A1 | Hydroxy substituted amides for the treatment of alzheimer's disease | PHARMACIA & UPJOHN | 2005-02-17 | — | — | US | disclosed |
| EP-1443923-A1 | HYDROXY SUBSTITUTED AMIDES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | Elan Pharmaceuticals, Inc. (US) | 2004-08-11 | — | — | EP | disclosed |
| WO-2003037325-A1 | HYDROXY SUBSTITUTED AMIDES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | ELAN PHARMACEUTICALS, INC. (US) | 2003-05-08 | — | — | WO | disclosed |
| EP-0650476-B1 | PERIPHERAL VASODILATING AGENT CONTAINING N-ACYLATED 4-AMINO PIPERIDINE DERIVATIVES AS ACTIVE INGREDIENTS | OTSUKA PHARMA CO LTD (JP) | 2002-06-26 | — | — | EP | disclosed |
| US-6136826-A | AMINOPIPERIDINE COMPOUNDS SUBSTITUTED WITH ALKANOYL | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2000-10-24 | — | — | US | disclosed |
| US-5760058-A | Peripheral vasodilating agent containing piperidine derivative as active ingredient | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1998-06-02 | — | — | US | disclosed |
| US-5747540-A | ENZYME INHIBITORS HYDROXY INDOLEAMIDES, COUMARIN AMIDES AND ISOTHIOCOUMARIN AMIDES | MERCK & CO., INC. (US) | 1998-05-05 | — | — | US | disclosed |
| US-5656642-A | Peripheral vasodilating agent containing piperidine derivative as active ingredient | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-08-12 | — | — | US | disclosed |
| WO-1994022826-A1 | PERIPHERAL VASODILATING AGENT CONTAINING N-ACYLATED 4-AMINO PIPERIDINE DERIVATIVES AS ACTIVE INGREDIENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-10-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050038019-A1 | Hydroxy substituted amides for the treatment of alzheimer's disease | BACE1, APP, BACE2 | KMT2A 1547/4885MEN1 3526/4885GAA 31/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.