Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 10/20 | 0.40 |
| ▸ | TACR1 | P25103 | 1/20 | 0.39 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.33 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2725259 | 0.76 | BACE1 (0.45) | BACE1BACE2KMT2AALDH1A1HPGD | |
| SCHEMBL2725260 | 0.76 | BACE1 (0.45) | BACE1BACE2KMT2AALDH1A1HPGD | |
| SCHEMBL6468829 | 0.76 | SCD5 (0.34) | BACE1 | |
| SCHEMBL8277927 | 0.73 | BACE1 (0.38) | BACE1TACR1KDM4ENPSR1 | |
| SCHEMBL4944316 | 0.71 | BACE1 (0.44) | BACE1TACR1BACE2HDAC1 | |
| SCHEMBL15047148 | 0.69 | GAA (0.54) | TACR1KMT2AALDH1A1HPGDHDAC6 | |
| SCHEMBL13828053 | 0.69 | GAA (0.54) | TACR1KMT2AALDH1A1HPGDHDAC6 | |
| SCHEMBL6467155 | 0.69 | BACE1 (0.39) | BACE1BACE2CES1KMT2AALDH1A1 | |
| SCHEMBL4942415 | 0.68 | BACE1 (0.37) | BACE1BACE2ALDH1A1TP53MAPT | |
| SCHEMBL2727492 | 0.68 | BACE1 (0.46) | BACE1BACE2KMT2AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012054510-A1 | OXADIAZOLE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF | COMENTIS, INC. (US) | 2012-04-26 | — | — | WO | disclosed |