Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 1/20 | 0.43 |
| ▸ | MPO | P05164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6468566 | 0.89 | PLA2G2A (0.42) | PLA2G2AMPOALDH1A1KDM4EHPGD | |
| SCHEMBL3919213 | 0.88 | PLA2G2A (0.48) | PLA2G2AMPOALDH1A1HPGDNPSR1 | |
| SCHEMBL6468559 | 0.81 | ALDH1A1 (0.54) | ALDH1A1KDM4EHPGDHSD17B10NPSR1 | |
| SCHEMBL6468967 | 0.80 | POLB (0.51) | PLA2G2AALDH1A1HPGDNPSR1KMT2A | |
| SCHEMBL3917726 | 0.80 | PLA2G2A (0.50) | PLA2G2AMPOALDH1A1KDM4EHSD17B10 | |
| SCHEMBL3917698 | 0.77 | ALDH1A1 (0.55) | PLA2G2AALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL3931017 | 0.77 | ALDH1A1 (0.58) | PLA2G2AALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL3918365 | 0.77 | ALDH1A1 (0.58) | PLA2G2AALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL3917712 | 0.76 | ALDH1A1 (0.57) | PLA2G2AALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL3919700 | 0.76 | POLB (0.54) | PLA2G2AALDH1A1NPSR1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1583742-A1 | NOVEL CB 1 RECEPTOUR INVERSE AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-10-12 | — | — | EP | claimed |
| WO-2004060870-A1 | NOVEL CB 1 RECEPTOUR INVERSE AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-07-22 | — | — | WO | claimed |
| EP-1583742-A1 | NOVEL CB 1 RECEPTOUR INVERSE AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-10-12 | — | — | EP | disclosed |
| WO-2004060870-A1 | NOVEL CB 1 RECEPTOUR INVERSE AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-07-22 | — | — | WO | disclosed |