Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | HTR4 | Q13639 | 3/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 3/20 | 0.40 |
| ▸ | HTR2C | P28335 | 3/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3919700 | 0.96 | POLB (0.54) | POLBHTR4ACHETDP1PDE10A | |
| SCHEMBL13717119 | 0.92 | HTR4 (0.50) | POLBHTR4ACHETDP1PDE10A | |
| SCHEMBL3919213 | 0.91 | PLA2G2A (0.48) | POLBNOTUMPLA2G2AALDH1A1MAPT | |
| SCHEMBL13716928 | 0.87 | ALDH1A1 (0.49) | POLBPLA2G2AALDH1A1MAPTMEN1 | |
| SCHEMBL13716929 | 0.87 | ALDH1A1 (0.45) | POLBPLA2G2AALDH1A1MAPTMEN1 | |
| SCHEMBL3919099 | 0.86 | MEN1 (0.47) | POLBHTR4ACHEMAPTMEN1 | |
| SCHEMBL13716872 | 0.85 | CNR1 (0.46) | POLBPLA2G2AALDH1A1MAPTMEN1 | |
| SCHEMBL3921491 | 0.85 | ALDH1A1 (0.47) | POLBPLA2G2AALDH1A1MAPTMEN1 | |
| SCHEMBL13717054 | 0.85 | ALDH1A1 (0.46) | POLBPLA2G2AALDH1A1MAPTMEN1 | |
| SCHEMBL13716656 | 0.85 | DRD2 (0.56) | MAPTLMNASLC6A4DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1583742-A1 | NOVEL CB 1 RECEPTOUR INVERSE AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-10-12 | — | — | EP | claimed |
| WO-2004060870-A1 | NOVEL CB 1 RECEPTOUR INVERSE AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-07-22 | — | — | WO | claimed |