Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 9/20 | 0.53 |
| ▸ | PLA2G10 | O15496 | 8/20 | 0.53 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.49 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 2/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.41 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.41 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.41 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.41 |
| ▸ | PLA2G12B | Q9BX93 | 1/20 | 0.41 |
| ▸ | PLA2G12A | Q9BZM1 | 1/20 | 0.41 |
| ▸ | PLA2G2F | Q9BZM2 | 1/20 | 0.41 |
| ▸ | PLA2G3 | Q9NZ20 | 1/20 | 0.41 |
| ▸ | PLA2G2E | Q9NZK7 | 1/20 | 0.41 |
| ▸ | PLA2G2D | Q9UNK4 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12394323 | 0.76 | MCL1 (0.50) | LMNANPC1ALDH1A1TP53GLA | |
| SCHEMBL3789578 | 0.76 | BTK (0.51) | BTKBRD4BCAT2PLA2G1BLMNA | |
| SCHEMBL27621512 | 0.74 | BTK (0.50) | BTKBRD4BCAT2ALDH1A1CYP3A4 | |
| SCHEMBL12394303 | 0.73 | MAOB (0.52) | ALDH1A1MAPK1SMN1; SMN2HDAC8MAOB | |
| SCHEMBL1250166 | 0.73 | BCAT2 (0.61) | BTKBRD4BCAT2NPC1ALDH1A1 | |
| SCHEMBL7071495 | 0.71 | HDAC1 (0.50) | NPC1ALDH1A1MAPK1RAB9ASMN1; SMN2 | |
| SCHEMBL6685340 | 0.70 | BTK (0.46) | BTKBRD4BCAT2NPC1ALDH1A1 | |
| SCHEMBL23646005 | 0.69 | PLA2G2A (1.00) | PLA2G2APLA2G10SLCO1B1PLA2G1BPLA2G5 | |
| SCHEMBL30411519 | 0.69 | PLA2G2A (1.00) | PLA2G2APLA2G10SLCO1B1PLA2G1BPLA2G5 | |
| SCHEMBL3376462 | 0.69 | SIRT2 (0.50) | ADRA1DSIRT2LMNANPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551795-A1 | INHIBITORS OF HISTONE DEACETYLASE | Methylgene, Inc. (CA) | 2005-07-13 | — | — | EP | disclosed |
| WO-2004035525-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2004-04-29 | — | — | WO | disclosed |